SynBio Pharmaceutical Lab 合成生物药物实验室

We engineer programmable therapeutic systems at the intersection of synthetic biology and nucleic acid nanotechnology.

合成生物药物实验室专注三方面研究: 1)核酸折纸结构的设计与功能化，及其在药剂学中的纳米药物应用; 2)基于人工智能的合成生物学策略在免疫治疗中的应用探索; 3)合成细胞的构建与调控，及其在生物药剂学中的创新转化应用

Lab Members 课题组成员

王蛘

四川大学华西药学院特聘研究员，博士生导师; 国家自然科学基金优秀青年科学基金项目（海外）

胡杨

2025年入学博士生

谢广能

2025年入学硕士生

徐安然

2025年入学硕士生

Publications 已发表研究论文

Wang Yang, Igor Baars, Ieva Berzina, Iris Rocamonde-Lago, Boxuan Shen, Yunshi Yang, Marco Lolaico, Janine Waldvogel, Ioanna Smyrlaki, Keying Zhu, Robert A Harris, Björn Högberg*. A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns. Nature Nanotechnology. 19, pages 1366–1374 (2024)
Ioanna Smyrlaki, Ferenc Fördős, Iris Rocamonde-Lago, Wang Yang, Boxuan Shen, Antonio Lentini, Vincent C Luca, Björn Reinius, Ana I Teixeira, Björn Högberg*. Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force. Nature Communications. 15, Article number: 465 (2024).
Marco Lolaico, Sebbe Blokhuizen, Boxuan Shen, Wang Yang, Björn Högberg*. Computer-Aided Design of A-Trail Routed Wireframe DNA Nanostructures with Square Lattice Edges. ACS Nano. 17, 7, 6565–6574 (2023).
Miao Deng, Rong Guo, Wang Yang, Jia-Xin Li, Jiao He, Man Li*, and Qin He*. Curbing Exosome Communications via Introducing Artificial Membrane Receptors for Metastatic Pancreatic Cancer Therapy. Advanced Materials. 35, 2303736 (2023).
Jiaye Liu#, Wang Yang#(co-first), Chunyang Mu#, Meng Li, Kewei Li, Shan Li, Wenshuang Wu, Lingyao Du, Xiaoyun Zhang, Chuan Li, Wei Peng, Junyi Shen, Yang Liu, Dujiang Yang, Kaixiang Zhang, Qingyang Ning, Xiaoying Fu, Yu Zeng, Yinyun Ni, Zongguang Zhou, Yi Liu, Yiguo Hu, Xiaofeng Zheng*, Tianfu Wen*, Zhihui Li*, Yong Liu*. Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement. Nature Communications. 13, Article number: 4308 (2022).
Keying Zhu, Wang Yang, Heela Sarlus, Keyi Geng, Erik Nutma, Jingxian Sun, Shin‐Yu Kung, Cindy Bay, Jinming Han, Jin‐Hong Min, Irene Benito‐Cuesta, Harald Lund, Sandra Amor, Jun Wang, Xing‐Mei Zhang, Claudia Kutter, André Ortlieb Guerreiro‐Cacais, Björn Högberg, Robert A Harris*. Myeloid cell‐specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation. EMBO Reports. 23: e54499 (2022).
Wang Yang, Erik Benson, Ferenc Fördős, Marco Lolaico, Igor Baars, Trixy Fang, Ana I Teixeira, Björn Högberg*. DNA Origami Penetration in Cell Spheroid Tissue Models is Enhanced by Wireframe Design. Advanced Materials. 33, 2008457 (2021).
Wang Yang, Igor Baars, Ferenc Fördős, Björn Högberg*. Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides. ACS Nano. 15, 6, 9614–9626 (2021).
Toon Verheyen, Trixy Fang, Dominik Lindenhofer, Wang Yang, Karen Akopyan, Arne Lindqvist, Björn Högberg, Ana I Teixeira*. Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers. Nucleic Acid Research. 48, 5777–5787 (2020).

Conference paper 会议论文

3) 2025年6月,中国化学会第十二届DNA纳米技术研讨会,英文学术报告 (中国,成都),报告题目《Triplex DNA-MediatedLigandExposure for Tumor-Selective Cell Killing》; 2) 2024年4月,第21届纳米科学基础年度会议（FNANO2024),英文学术报告 (美国,snowbird),报告题目《A DNA-Based Robotic Device Exhibiting Controlled and Autonomous Presentation of Nano-patterned Cytotoxic Ligands in vivo》; 1) 2023年4月,第21届纳米科学基础年度会议（FNANO2024),英文学术报告 (美国,snowbird),报告题目《2024年4月,第21届纳米科学基础年度会议（FNANO2024),英文学术报告 (美国,snowbird),报告题目《Wireframe DNA origami engineering for immunotherapy》.

Contact 联系方式

Address: 四川省成都市人民南路三段17号四川大学华西药学院，邮编：610041 Email: yang_wang@scu.edu.cn; wangyangkiscu@gmail.com

Collaborators 合作伙伴

四川大学华西药学院 • 哈佛医学院 Harvard Medical School & 丹娜法博癌症研究所 Dana-Farber Cancer Institute (Ming-Ru Wu Lab) • 卡罗林斯卡医学院 Karolinska Institute (Björn Högberg Lab)

Group Introduction