Group Introduction

Group Introduction

SynBio Pharmaceutical Lab

We engineer programmable therapeutic systems at the intersection of synthetic biology and nucleic acid nanotechnology.

合成生物药物实验室专注于可编程治疗策略的构建，融合 DNA/RNA origami、基因电路与药物递送系统，推动精准药物与未来药剂学的发展。

Lab Members

王蛘

海纳特聘教授，特聘研究员

谢广能

Graduate Student

徐安然

Graduate Student

Publications

1. Wang Yang, Igor Baars, Ieva Berzina, Iris Rocamonde-Lago, Boxuan Shen, Yunshi Yang, Marco Lolaico, Janine Waldvogel, Ioanna Smyrlaki, Keying Zhu, Robert A Harris, Björn Högberg*. A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns. Nature Nanotechnology. 19, pages 1366–1374 (2024)
2. Ioanna Smyrlaki, Ferenc Fördős, Iris Rocamonde-Lago, Wang Yang, Boxuan Shen, Antonio Lentini, Vincent C Luca, Björn Reinius, Ana I Teixeira, Björn Högberg*. Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force. Nature Communications. 15, Article number: 465 (2024).
3. Marco Lolaico, Sebbe Blokhuizen, Boxuan Shen, Wang Yang, Björn Högberg*. Computer-Aided Design of A-Trail Routed Wireframe DNA Nanostructures with Square Lattice Edges. ACS Nano. 17, 7, 6565–6574 (2023).
4. Miao Deng, Rong Guo, Wang Yang, Jia-Xin Li, Jiao He, Man Li*, and Qin He*. Curbing Exosome Communications via Introducing Artificial Membrane Receptors for Metastatic Pancreatic Cancer Therapy. Advanced Materials. 35, 2303736 (2023).
5. Jiaye Liu#, Wang Yang#(co-first), Chunyang Mu#, Meng Li, Kewei Li, Shan Li, Wenshuang Wu, Lingyao Du, Xiaoyun Zhang, Chuan Li, Wei Peng, Junyi Shen, Yang Liu, Dujiang Yang, Kaixiang Zhang, Qingyang Ning, Xiaoying Fu, Yu Zeng, Yinyun Ni, Zongguang Zhou, Yi Liu, Yiguo Hu, Xiaofeng Zheng*, Tianfu Wen*, Zhihui Li*, Yong Liu*. Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement. Nature Communications. 13, Article number: 4308 (2022).
6. Keying Zhu, Wang Yang, Heela Sarlus, Keyi Geng, Erik Nutma, Jingxian Sun, Shin‐Yu Kung, Cindy Bay, Jinming Han, Jin‐Hong Min, Irene Benito‐Cuesta, Harald Lund, Sandra Amor, Jun Wang, Xing‐Mei Zhang, Claudia Kutter, André Ortlieb Guerreiro‐Cacais, Björn Högberg, Robert A Harris*. Myeloid cell‐specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation. EMBO Reports. 23: e54499 (2022).
7. Wang Yang, Erik Benson, Ferenc Fördős, Marco Lolaico, Igor Baars, Trixy Fang, Ana I Teixeira, Björn Högberg*. DNA Origami Penetration in Cell Spheroid Tissue Models is Enhanced by Wireframe Design. Advanced Materials. 33, 2008457 (2021).
8. Wang Yang, Igor Baars, Ferenc Fördős, Björn Högberg*. Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides. ACS Nano. 15, 6, 9614–9626 (2021).
9. Toon Verheyen, Trixy Fang, Dominik Lindenhofer, Wang Yang, Karen Akopyan, Arne Lindqvist, Björn Högberg, Ana I Teixeira*. Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers. Nucleic Acid Research. 48, 5777–5787 (2020).

Contact

Address: 成都市人民南路三段四川大学华西药学院
Email: yang.wang@ki.se

Team Photo