Group Introduction

SynBio Pharmaceutical Lab

We engineer programmable therapeutic systems at the intersection of synthetic biology and nucleic acid nanotechnology.

合成生物药物实验室专注于可编程治疗策略的构建，融合 DNA/RNA origami、基因电路与药物递送系统，推动精准药物与未来药剂学的发展。

Lab Members

     <img src="/path/to/wangyang.jpg" alt="Wang Yang" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">

王蛘

Professor, PI

     <img src="/path/to/xieguangneng.jpg" alt="谢广能" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">

谢广能

Graduate Student

     <img src="/path/to/xuanran.jpg" alt="徐安然" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">

徐安然

Graduate Student

Team Photo

   <img src="/path/to/team-photo.jpg" alt="Group Photo" style="max-width: 100%; border-radius: 12px;">

Contact

   Address: [Your Lab Address Here]

   Email: [youremail@example.com]

   Tel: +[Your Phone Number]

Collaborators

   <img src="/path/to/institute1-logo.png" alt="Institute 1" style="height: 60px;">
   <img src="/path/to/institute2-logo.png" alt="Institute 2" style="height: 60px;">

Publications

1. Wang Yang, Igor Baars, ... A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns. Nature Nanotechnology. 19, pages1366–1374 (2024) <a href="/files/paper1.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
2. Ioanna Smyrlaki, Ferenc Fördős, ... Wang Yang, ... Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force. Nature Communications. 15, 465 (2024) <a href="/files/paper2.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
3. Marco Lolaico, ... Wang Yang, Björn Högberg*. Computer-Aided Design of A-Trail Routed Wireframe DNA Nanostructures with Square Lattice Edges. ACS Nano. 17, 6565–6574 (2023) <a href="/files/paper3.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
4. Miao Deng, Rong Guo, Wang Yang, ... Curbing Exosome Communications for Metastatic Pancreatic Cancer Therapy. Advanced Materials. 35, 2303736 (2023) <a href="/files/paper4.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
5. Jiaye Liu#, Wang Yang# ... Pancreatic tumor eradication via selective Pin1 inhibition in CAFs and T cells. Nature Communications. 13, 4308 (2022) <a href="/files/paper5.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
6. Keying Zhu, Wang Yang, ... Myeloid-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation. EMBO Reports. 23: e54499 (2022) <a href="/files/paper6.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
7. Wang Yang, Erik Benson, ... DNA Origami Penetration in Cell Spheroid Models Enhanced by Wireframe Design. Advanced Materials. 33, 2008457 (2021) <a href="/files/paper7.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
8. Wang Yang, Igor Baars, ... Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides. ACS Nano. 15, 9614–9626 (2021) <a href="/files/paper8.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
9. Toon Verheyen, Wang Yang, ... Spatial organization-dependent EphA2 transcriptional responses. Nucleic Acid Research. 48, 5777–5787 (2020) <a href="/files/paper9.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>