Synthetic BioPharmaceutics Group

（合成生物药剂学课题组）

🔬 Research Focus

DNA/RNA Origami for Therapy

Design of 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with precise spatial control and responsiveness to tumor cues.

Logic-Gated Immune Activation

We engineer aptamer–antibody logic systems and RNA circuits that enable conditional T cell activation within immunosuppressive tumor environments.

Peptide–DNA Conjugates for Receptor Clustering

We create pH-responsive peptide–DNA materials that self-assemble in acidic tumor microenvironments to cluster death receptors (e.g., TRAIL-R) and induce apoptosis.

👤 Current Members

Yang Wang 王蛘

Professor 海纳特聘教授(特聘研究员)

国家级青年人才

Xie Guangneng 谢广能

Student 研究生

Xu Anran 徐安然

PhD Student 研究生

Zhang Wei

Master Student

Li Jie

Intern

📚 Selective Publications 代表性论文

Wang Y, et al. Programmable DNA robot for cancer therapy. Nature Nanotechnology, 2024.
Wang Y, et al. RNA origami logic gates for T cell activation. Nature Biomedical Engineering, 2023.

📞 Contact

📍 West China School of Pharmacy, Sichuan University

📧 13547820971@163.com

🌐 yangwalab.com