Yangwa:GroupIntro
🧬 About Our Lab
We are a synthetic biology lab focusing on programmable molecular systems for precision immunotherapy and intracellular control. Our mission is to engineer intelligent biomaterials and RNA circuits to reprogram cellular functions in disease contexts.
🔬 Research Focus
1. DNA/RNA Origami for Therapy
Design of 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with spatial precision and responsiveness to tumor cues.
2. Logic-Gated Immune Activation
Development of antibody–aptamer systems and synthetic RNA circuits for T cell activation only under tumor-specific conditions.
3. Peptide–DNA Conjugates
Construction of self-assembling chains to cluster death receptors (e.g., TRAIL-R) via pH-triggered ligand assembly in the tumor microenvironment.
👥 Current Members
Yang Wang, PhD
Principal Investigator
Guangneng Xie
Master Student
Anran Xu
Master Student
📚 Selected Publications
- Wang Y et al. *Aptamer logic-guided T cell activation in pancreatic cancer*. Nature Biotech, 2025.
- Wang Y et al. *pH-programmable peptide-DNA nanostructures for apoptosis induction*. Nature Nanotechnology, 2024.