SynBio Pharmaceutical Lab

We are a synthetic biology research group committed to engineering programmable therapeutic systems.

合成生物药物实验室聚焦于可编程治疗系统的开发，融合 DNA/RNA 折纸技术、基因电路设计与智能药物递送体系，致力于解决重大疾病的治疗瓶颈，推动精准药物与未来药剂学的前沿发展。

Lab Members

     <img src="/path/to/wangyang.jpg" alt="Wang Yang" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">

王蛘

PI

     <img src="/path/to/xieguangneng.jpg" alt="谢广能" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">

谢广能

Graduate Student

     <img src="/path/to/xuanran.jpg" alt="徐安然" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">

徐安然

Graduate Student

Publications

Wang Yang, Igor Baars, Ieva Berzina, Iris Rocamonde-Lago, Boxuan Shen, Yunshi Yang, Marco Lolaico, Janine Waldvogel, Ioanna Smyrlaki, Keying Zhu, Robert A Harris, Björn Högberg*. A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns. Nature Nanotechnology. 19, pages1366–1374 (2024)
Ioanna Smyrlaki, Ferenc Fördős, Iris Rocamonde-Lago, Wang Yang, Boxuan Shen, Antonio Lentini, Vincent C Luca, Björn Reinius, Ana I Teixeira, Björn Högberg*. Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force. Nature Communications. 15, Article number: 465 (2024).
Marco Lolaico, Sebbe Blokhuizen, Boxuan Shen, Wang Yang, Björn Högberg*. Computer-Aided Design of A-Trail Routed Wireframe DNA Nanostructures with Square Lattice Edges. ACS Nano. 17, 7, 6565–6574 (2023).
Jiaye Liu#, Yang Wang# (co-first), Chunyang Mu#, Meng Li, Kewei Li, Shan Li, Wenshuang Wu, Lingyao Du, Xiaoyun Zhang, Chuan Li, Wei Peng, Junyi Shen, Yang Liu, Dujiang Yang, Kaixiang Zhang, Qingyang Ning, Xiaoying Fu, Yu Zeng, Yinyun Ni, Zongguang Zhou, Yi Liu, Yiguo Hu, Xiaofeng Zheng*, Tianfu Wen*, Zhihui Li*, Yong Liu*. Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement. Nature Communications. 13, Article number: 4308 (2022).

Contact

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Collaborators

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