Yangwa:GroupIntro
Research Focus
🔬 DNA/RNA Origami for Therapy
Design of 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with precise spatial control and responsiveness to tumor cues.🧠 Logic-Gated Immune Activation
We engineer aptamer–antibody logic systems and RNA circuits that enable conditional T cell activation within immunosuppressive tumor environments.🧬 Peptide–DNA Conjugates for Receptor Clustering
We create pH-responsive peptide–DNA materials that self-assemble in acidic tumor microenvironments to cluster death receptors (e.g., TRAIL-R) and induce apoptosis.Current Members
Yang Wang
Principal Investigator
Xie Guangneng
PhD Student
Xu Anran
PhD Student
Publications
- Wang Y, et al. Programmable DNA robot for cancer therapy. Nature Nanotechnology, 2024.
- Wang Y, et al. RNA origami logic gates for T cell activation. Nature Biomedical Engineering, 2023.
Contact
📍 West China School of Pharmacy, Sichuan University
📧 yangwa@lab.edu