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<!-- 🔝 顶部导航菜单 -->
<div style="max-width: 960px; margin: 0 auto; padding: 40px 20px; font-family: 'Segoe UI', sans-serif;">
<div style="text-align: center; margin-bottom: 60px; font-size: 16px; background-color: #f9f9f9; padding: 12px 0; border-bottom: 1px solid #ccc;">
  <a href="#home" style="margin: 0 20px; color: #007BFF; text-decoration: none;">HOME</a>
  <a href="#goals" style="margin: 0 20px; color: #007BFF; text-decoration: none;">GOALS</a>
  <a href="#research" style="margin: 0 20px; color: #007BFF; text-decoration: none;">RESEARCH</a>
  <a href="#teaching" style="margin: 0 20px; color: #007BFF; text-decoration: none;">TEACHING</a>
  <a href="#people" style="margin: 0 20px; color: #007BFF; text-decoration: none;">PEOPLE</a>
  <a href="#publications" style="margin: 0 20px; color: #007BFF; text-decoration: none;">PUBLICATIONS</a>
  <a href="#contact" style="margin: 0 20px; color: #007BFF; text-decoration: none;">CONTACT</a>
</div>
 
<div id="home" style="width: 100%; padding: 60px 40px; font-family: 'Segoe UI', sans-serif; color: #222; box-sizing: border-box;">
 
   <!-- 🧬 实验室简介 -->
   <!-- 🧬 实验室简介 -->
   <h1 style="text-align: center; font-size: 36px; font-weight: bold; margin-bottom: 20px;">SynBio Pharmaceutical Lab</h1>
   <h1 style="text-align: center; font-size: 32px; font-weight: bold;">SynBio Pharmaceutical Lab</h1>
   <p style="text-align: center; font-size: 18px; line-height: 1.6; margin-bottom: 10px;">
   <p style="text-align: center; font-size: 18px; margin-bottom: 8px;">
     We are a synthetic biology research group committed to engineering programmable therapeutic systems.
     We engineer programmable therapeutic systems at the intersection of synthetic biology and nucleic acid nanotechnology.
   </p>
   </p>
   <p id="goals" style="text-align: center; font-size: 16px; line-height: 1.6; color: #555;">
   <p style="text-align: center; font-size: 15px; color: #444; margin-bottom: 40px;">
     合成生物药物实验室聚焦于可编程治疗系统的开发，融合 DNA/RNA 折纸技术、基因电路设计与智能药物递送体系，致力于解决重大疾病的治疗瓶颈，推动精准药物与未来药剂学的前沿发展。
     合成生物药物实验室专注于可编程治疗策略的构建，融合 DNA/RNA origami、基因电路与药物递送系统，推动精准药物与未来药剂学的发展。
   </p>
   </p>
  <!-- 📚 研究和教学（可补充内容） -->
  <h2 id="research" style="text-align: center; font-size: 26px; margin-top: 80px;">Research</h2>
  <p style="text-align: center; font-size: 15px; color: #555;">[Add research overview here]</p>
  <h2 id="teaching" style="text-align: center; font-size: 26px; margin-top: 80px;">Teaching</h2>
  <p style="text-align: center; font-size: 15px; color: #555;">[Add teaching description here]</p>


   <!-- 👥 实验室成员 -->
   <!-- 👥 实验室成员 -->
   <h2 id="people" style="text-align: center; font-size: 26px; margin-top: 80px;">Lab Members</h2>
   <h2 style="text-align: center; font-size: 24px; margin-top: 60px;">Lab Members</h2>
   <div style="display: flex; justify-content: center; flex-wrap: wrap; gap: 40px; margin-top: 30px;">
   <div style="display: flex; justify-content: center; flex-wrap: wrap; gap: 40px; margin-top: 30px;">
     <div style="text-align: center; width: 160px;">
     <div style="text-align: center; width: 160px;">
       <img src="/path/to/wangyang.jpg" alt="Wang Yang" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">
       <img src="/path/to/wangyang.jpg" alt="Wang Yang" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">
       <div style="font-weight: bold; margin-top: 10px;">王蛘</div>
       <div style="font-weight: bold; margin-top: 10px;">王蛘</div>
       <div style="font-size: 14px; color: #666;">PI</div>
       <div style="font-size: 14px; color: #666">Professor, PI</div>
     </div>
     </div>
     <div style="text-align: center; width: 160px;">
     <div style="text-align: center; width: 160px;">
       <img src="/path/to/xieguangneng.jpg" alt="谢广能" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">
       <img src="/path/to/xieguangneng.jpg" alt="谢广能" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">
       <div style="font-weight: bold; margin-top: 10px;">谢广能</div>
       <div style="font-weight: bold; margin-top: 10px;">谢广能</div>
       <div style="font-size: 14px; color: #666;">Graduate Student</div>
       <div style="font-size: 14px; color: #666">Graduate Student</div>
     </div>
     </div>
     <div style="text-align: center; width: 160px;">
     <div style="text-align: center; width: 160px;">
       <img src="/path/to/xuanran.jpg" alt="徐安然" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">
       <img src="/path/to/xuanran.jpg" alt="徐安然" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">
       <div style="font-weight: bold; margin-top: 10px;">徐安然</div>
       <div style="font-weight: bold; margin-top: 10px;">徐安然</div>
       <div style="font-size: 14px; color: #666;">Graduate Student</div>
       <div style="font-size: 14px; color: #666">Graduate Student</div>
     </div>
     </div>
  </div>
  <!-- 📸 团队合照 -->
  <h2 style="text-align: center; font-size: 24px; margin-top: 80px;">Team Photo</h2>
  <div style="text-align: center; margin-top: 20px;">
    <img src="/path/to/team-photo.jpg" alt="Group Photo" style="max-width: 100%; border-radius: 12px;">
  </div>
  <!-- 📞 联系方式 -->
  <h2 style="text-align: center; font-size: 24px; margin-top: 80px;">Contact</h2>
  <div style="text-align: center; font-size: 15px; margin-top: 10px; color: #444;">
    Address: [Your Lab Address Here]<br>
    Email: [youremail@example.com]<br>
    Tel: +[Your Phone Number]
  </div>
  <!-- 🤝 合作机构 -->
  <h2 style="text-align: center; font-size: 24px; margin-top: 80px;">Collaborators</h2>
  <div style="display: flex; justify-content: center; flex-wrap: wrap; gap: 40px; margin-top: 20px;">
    <img src="/path/to/institute1-logo.png" alt="Institute 1" style="height: 60px;">
    <img src="/path/to/institute2-logo.png" alt="Institute 2" style="height: 60px;">
   </div>
   </div>


   <!-- 📚 发表文章 -->
   <!-- 📚 发表文章 -->
   <h2 id="publications" style="text-align: center; font-size: 26px; margin-top: 80px;">Publications</h2>
   <h2 style="text-align: center; font-size: 26px; margin-top: 80px;">Publications</h2>
   <div style="width: 100%; font-size: 15px; color: #333; line-height: 1.8; text-align: left; box-sizing: border-box;">
   <div style="width: 100%; font-size: 15px; color: #333; line-height: 1.8; text-align: left; box-sizing: border-box;">
     <ol style="padding-left: 40px;">
     <ol style="padding-left: 40px;">
       <li>
       <li>
         <span style="color: #007BFF; text-decoration: underline;">Wang Yang</span>, Igor Baars, Ieva Berzina, Iris Rocamonde-Lago, Boxuan Shen, Yunshi Yang, Marco Lolaico, Janine Waldvogel, Ioanna Smyrlaki, Keying Zhu, Robert A Harris, Björn Högberg*.   
         <span style="text-decoration: underline;">Wang Yang</span>, Igor Baars, ...   
         <strong>A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns</strong>.   
         <strong>A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns</strong>.   
         <em style="color: #007BFF;">Nature Nanotechnology</em>. 19, pages1366–1374 (2024)
         <em style="color: #007BFF;">Nature Nanotechnology</em>. 19, pages1366–1374 (2024)
        <a href="/files/paper1.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
       </li>
       </li>
       <li>
       <li>
         Ioanna Smyrlaki, Ferenc Fördős, Iris Rocamonde-Lago, <span style="color: #007BFF;">Wang Yang</span>, Boxuan Shen, Antonio Lentini, Vincent C Luca, Björn Reinius, Ana I Teixeira, Björn Högberg*.   
         Ioanna Smyrlaki, Ferenc Fördős, ... <span style="text-decoration: underline;">Wang Yang</span>, ...   
         <strong>Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force</strong>.   
         <strong>Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force</strong>.   
         <em style="color: #007BFF;">Nature Communications</em>. 15, Article number: 465 (2024).
         <em style="color: #007BFF;">Nature Communications</em>. 15, 465 (2024)
        <a href="/files/paper2.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
       </li>
       </li>
       <li>
       <li>
         Jiaye Liu#, <span style="color: #007BFF;">Yang Wang# (co-first)</span>, Chunyang Mu#, Meng Li, Kewei Li, Shan Li, Wenshuang Wu, Lingyao Du, Xiaoyun Zhang, Chuan Li, Wei Peng, Junyi Shen, Yang Liu, Dujiang Yang, Kaixiang Zhang, Qingyang Ning, Xiaoying Fu, Yu Zeng, Yinyun Ni, Zongguang Zhou, Yi Liu, Yiguo Hu, Xiaofeng Zheng*, Tianfu Wen*, Zhihui Li*, Yong Liu*.   
         Marco Lolaico, ... <span style="text-decoration: underline;">Wang Yang</span>, Björn Högberg*. 
         <strong>Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement</strong>.   
        <strong>Computer-Aided Design of A-Trail Routed Wireframe DNA Nanostructures with Square Lattice Edges</strong>. 
         <em style="color: #007BFF;">Nature Communications</em>. 13, Article number: 4308 (2022).
        <em style="color: #007BFF;">ACS Nano</em>. 17, 6565–6574 (2023)
        <a href="/files/paper3.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
      </li>
      <li>
        Miao Deng, Rong Guo, <span style="text-decoration: underline;">Wang Yang</span>, ... 
        <strong>Curbing Exosome Communications for Metastatic Pancreatic Cancer Therapy</strong>. 
        <em style="color: #007BFF;">Advanced Materials</em>. 35, 2303736 (2023)
        <a href="/files/paper4.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
      </li>
      <li>
        Jiaye Liu#, <span style="text-decoration: underline;">Wang Yang</span># ...   
         <strong>Pancreatic tumor eradication via selective Pin1 inhibition in CAFs and T cells</strong>.   
         <em style="color: #007BFF;">Nature Communications</em>. 13, 4308 (2022)
        <a href="/files/paper5.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
      </li>
      <li>
        Keying Zhu, <span style="text-decoration: underline;">Wang Yang</span>, ... 
        <strong>Myeloid-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation</strong>. 
        <em style="color: #007BFF;">EMBO Reports</em>. 23: e54499 (2022)
        <a href="/files/paper6.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
      </li>
      <li>
        <span style="text-decoration: underline;">Wang Yang</span>, Erik Benson, ... 
        <strong>DNA Origami Penetration in Cell Spheroid Models Enhanced by Wireframe Design</strong>. 
        <em style="color: #007BFF;">Advanced Materials</em>. 33, 2008457 (2021)
        <a href="/files/paper7.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
      </li>
      <li>
        <span style="text-decoration: underline;">Wang Yang</span>, Igor Baars, ... 
        <strong>Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides</strong>. 
        <em style="color: #007BFF;">ACS Nano</em>. 15, 9614–9626 (2021)
        <a href="/files/paper8.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
      </li>
      <li>
        Toon Verheyen, <span style="text-decoration: underline;">Wang Yang</span>, ... 
        <strong>Spatial organization-dependent EphA2 transcriptional responses</strong>. 
        <em style="color: #007BFF;">Nucleic Acid Research</em>. 48, 5777–5787 (2020)
        <a href="/files/paper9.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
       </li>
       </li>
     </ol>
     </ol>
    <p style="text-align: center; font-size: 14px; color: #777; margin-top: 20px;">
      For a complete list of publications, please visit my
      <a href="https://scholar.google.com/citations?hl=zh-CN&user=l59YAvcAAAAJ&view_op=list_works&sortby=pubdate"
        target="_blank"
        style="color: #007BFF; text-decoration: none;">
        Google Scholar
      </a>.
    </p>
   </div>
   </div>
  <!-- 📞 联系方式 -->
  <h2 id="contact" style="text-align: center; font-size: 26px; margin-top: 80px;">Contact</h2>
  <div style="text-align: center; font-size: 15px; color: #444; line-height: 1.8;">
    Address: [Your Lab Address Here]<br>
    Email: <a href="mailto:youremail@example.com" style="color: #007BFF;">youremail@example.com</a><br>
    Tel: +[Your Phone Number]
  </div>
  <!-- 🤝 合作机构 -->
  <h2 style="text-align: center; font-size: 26px; margin-top: 80px;">Collaborators</h2>
  <div style="display: flex; justify-content: center; flex-wrap: wrap; gap: 40px; margin-top: 20px;">
    <img src="/path/to/institute1-logo.png" alt="Institute 1" style="height: 60px;">
    <img src="/path/to/institute2-logo.png" alt="Institute 2" style="height: 60px;">
  </div>
  <!-- 🔢 访问统计 -->
  <p style="text-align: center; font-size: 14px; color: #888; margin-top: 60px;">
    🔢 This page has been viewed {{NUMBEROFVIEWS:{{PAGENAME}}}} times.
  </p>
</div>
</div>

Revision as of 04:02, 19 April 2025

SynBio Pharmaceutical Lab

We engineer programmable therapeutic systems at the intersection of synthetic biology and nucleic acid nanotechnology.

合成生物药物实验室专注于可编程治疗策略的构建，融合 DNA/RNA origami、基因电路与药物递送系统，推动精准药物与未来药剂学的发展。

Lab Members

     <img src="/path/to/wangyang.jpg" alt="Wang Yang" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">
王蛘
Professor, PI
     <img src="/path/to/xieguangneng.jpg" alt="谢广能" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">
谢广能
Graduate Student
     <img src="/path/to/xuanran.jpg" alt="徐安然" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">
徐安然
Graduate Student

Team Photo

   <img src="/path/to/team-photo.jpg" alt="Group Photo" style="max-width: 100%; border-radius: 12px;">

Contact

   Address: [Your Lab Address Here]

   Email: [youremail@example.com]

   Tel: +[Your Phone Number]

Collaborators

   <img src="/path/to/institute1-logo.png" alt="Institute 1" style="height: 60px;">
   <img src="/path/to/institute2-logo.png" alt="Institute 2" style="height: 60px;">

Publications

  1. Wang Yang, Igor Baars, ... A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns. Nature Nanotechnology. 19, pages1366–1374 (2024) <a href="/files/paper1.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
  2. Ioanna Smyrlaki, Ferenc Fördős, ... Wang Yang, ... Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force. Nature Communications. 15, 465 (2024) <a href="/files/paper2.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
  3. Marco Lolaico, ... Wang Yang, Björn Högberg*. Computer-Aided Design of A-Trail Routed Wireframe DNA Nanostructures with Square Lattice Edges. ACS Nano. 17, 6565–6574 (2023) <a href="/files/paper3.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
  4. Miao Deng, Rong Guo, Wang Yang, ... Curbing Exosome Communications for Metastatic Pancreatic Cancer Therapy. Advanced Materials. 35, 2303736 (2023) <a href="/files/paper4.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
  5. Jiaye Liu#, Wang Yang# ... Pancreatic tumor eradication via selective Pin1 inhibition in CAFs and T cells. Nature Communications. 13, 4308 (2022) <a href="/files/paper5.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
  6. Keying Zhu, Wang Yang, ... Myeloid-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation. EMBO Reports. 23: e54499 (2022) <a href="/files/paper6.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
  7. Wang Yang, Erik Benson, ... DNA Origami Penetration in Cell Spheroid Models Enhanced by Wireframe Design. Advanced Materials. 33, 2008457 (2021) <a href="/files/paper7.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
  8. Wang Yang, Igor Baars, ... Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides. ACS Nano. 15, 9614–9626 (2021) <a href="/files/paper8.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
  9. Toon Verheyen, Wang Yang, ... Spatial organization-dependent EphA2 transcriptional responses. Nucleic Acid Research. 48, 5777–5787 (2020) <a href="/files/paper9.pdf" style="margin-left: 10px; color: #007BFF;" target="_blank">📄 查看PDF</a>
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