Group Introduction

SynBio Pharmaceutical Lab

We are a synthetic biology research group committed to engineering programmable therapeutic systems.

合成生物药物实验室聚焦于可编程治疗系统的开发，融合 DNA/RNA 折纸技术、基因电路设计与智能药物递送体系，致力于解决重大疾病的治疗瓶颈，推动精准药物与未来药剂学的前沿发展。

Lab Members

     <img src="/path/to/wangyang.jpg" alt="Wang Yang" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">

王蛘

PI

     <img src="/path/to/xieguangneng.jpg" alt="谢广能" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">

谢广能

Graduate Student

     <img src="/path/to/xuanran.jpg" alt="徐安然" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">

徐安然

Graduate Student

Publications

1. Wang Yang, Igor Baars, Ieva Berzina, Iris Rocamonde-Lago, Boxuan Shen, Yunshi Yang, Marco Lolaico, Janine Waldvogel, Ioanna Smyrlaki, Keying Zhu, Robert A Harris, Björn Högberg*. A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns. Nature Nanotechnology. 19, pages1366–1374 (2024)
2. Ioanna Smyrlaki, Ferenc Fördős, Iris Rocamonde-Lago, Wang Yang, Boxuan Shen, Antonio Lentini, Vincent C Luca, Björn Reinius, Ana I Teixeira, Björn Högberg*. Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force. Nature Communications. 15, Article number: 465 (2024).
3. Marco Lolaico, Sebbe Blokhuizen, Boxuan Shen, Wang Yang, Björn Högberg*. Computer-Aided Design of A-Trail Routed Wireframe DNA Nanostructures with Square Lattice Edges. ACS Nano. 17, 7, 6565–6574 (2023).
4. Miao Deng, Rong Guo, Wang Yang, Jia-Xin Li, Jiao He, Man Li*, and Qin He*. Curbing Exosome Communications via Introducing ArtificialMembrane Receptors for Metastatic Pancreatic Cancer Therapy. Advanced Materials. 35, 2303736 (2023).
5. Jiaye Liu#, Wang Yang#(co-first), Chunyang Mu#, Meng Li, Kewei Li, Shan Li, Wenshuang Wu, Lingyao Du, Xiaoyun Zhang, Chuan Li, Wei Peng, Junyi Shen, Yang Liu, Dujiang Yang, Kaixiang Zhang, Qingyang Ning, Xiaoying Fu, Yu Zeng, Yinyun Ni, Zongguang Zhou, Yi Liu, Yiguo Hu, Xiaofeng Zheng*, Tianfu Wen*, Zhihui Li*, Yong Liu*. Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement. Nature Communications. 13, Article number: 4308 (2022).
6. Wang Yang, Erik Benson, Ferenc Fördős, Marco Lolaico, Igor Baars, Trixy Fang, Ana I Teixeira, Björn Högberg*. DNA Origami Penetration in Cell Spheroid Tissue Models is Enhanced by Wireframe Design. Advanced Materials. 33, 2008457 (2021).
7. Wang Yang, Igor Baars, Ferenc Fördös, Björn Högberg*. Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides. ACS Nano. 15, 6, 9614–9626 (2021).
8. Toon Verheyen, Trixy Fang, Dominik Lindenhofer, Wang Yang, Karen Akopyan, Arne Lindqvist, Björn Högberg, Ana I Teixeira*. Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers. Nucleic Acid Research. Vol. 48, No. 10 5777–5787 (2020).

Contact

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Collaborators

   <img src="/path/to/institute1-logo.png" alt="Institute 1" style="height: 60px;">
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