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= 👋 Welcome to the Lab of Synthetic Biopharmaceutics =
= 👋 Welcome to the Lab of Synthetic Biopharmaceutics =


We are a multidisciplinary team working at the intersection of **synthetic biology**, **DNA/RNA nanotechnology**, and **targeted drug delivery**. 
We are an interdisciplinary team developing programmable molecular systems for immunotherapy and targeted delivery.
Our mission is to develop programmable molecular systems for precision immunotherapy and intracellular control.


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== 🧠 Research Focus ==
== 👥 Current Members ==


== 👩‍🔬 Lab Members ==
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<!-- PI -->
<div style="width: 220px; text-align: center; background: #fff; border-radius: 16px; padding: 16px; box-shadow: 0 2px 10px rgba(0,0,0,0.08);">
  <img src="https://via.placeholder.com/200" style="width: 160px; height: 160px; border-radius: 50%; object-fit: cover; margin-bottom: 12px;" />
  <div style="font-weight: bold; font-size: 17px;">Dr. Yang Wang</div>
  <div style="color: #666;">Principal Investigator</div>
</div>


  <!-- PI -->
<!-- Student -->
  <div style="background-color: #1e1e1e; border: 1px solid #444; border-radius: 12px; padding: 16px; width: 280px; color: #eee; box-shadow: 0 2px 6px rgba(0,0,0,0.2);">
<div style="width: 220px; text-align: center; background: #fff; border-radius: 16px; padding: 16px; box-shadow: 0 2px 10px rgba(0,0,0,0.08);">
    <div style="font-weight: bold; font-size: 18px; margin-bottom: 6px;">Dr. Yang Wang</div>
  <img src="https://via.placeholder.com/200" style="width: 160px; height: 160px; border-radius: 50%; object-fit: cover; margin-bottom: 12px;" />
    <div style="font-size: 14px; margin-bottom: 6px;">Principal Investigator</div>
   <div style="font-weight: bold; font-size: 17px;">Guangneng Xie</div>
    <div style="font-size: 13px; color: #bbb;">DNA nanomedicine, synthetic biology</div>
  <div style="color: #666;">PhD Student</div>
    <div style="font-size: 13px; margin-top: 8px;">📧 yangwa@yourlab.org</div>
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  </div>
 
  <!-- Student 1 -->
   <div style="background-color: #1e1e1e; border: 1px solid #444; border-radius: 12px; padding: 16px; width: 280px; color: #eee; box-shadow: 0 2px 6px rgba(0,0,0,0.2);">
    <div style="font-weight: bold; font-size: 18px; margin-bottom: 6px;">Guangneng Xie</div>
    <div style="font-size: 14px; margin-bottom: 6px;">PhD Student</div>
    <div style="font-size: 13px; color: #bbb;">RNA origami, immune circuits</div>
  </div>


  <!-- Student 2 -->
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  <div style="background-color: #1e1e1e; border: 1px solid #444; border-radius: 12px; padding: 16px; width: 280px; color: #eee; box-shadow: 0 2px 6px rgba(0,0,0,0.2);">
    <div style="font-weight: bold; font-size: 18px; margin-bottom: 6px;">Anran Xu</div>
    <div style="font-size: 14px; margin-bottom: 6px;">PhD Student</div>
    <div style="font-size: 13px; color: #bbb;">DNA origami integrity, blood-based detection</div>
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  <!-- RA -->
  <div style="background-color: #1e1e1e; border: 1px solid #444; border-radius: 12px; padding: 16px; width: 280px; color: #eee; box-shadow: 0 2px 6px rgba(0,0,0,0.2);">
    <div style="font-weight: bold; font-size: 18px; margin-bottom: 6px;">Kang Wang</div>
    <div style="font-size: 14px; margin-bottom: 6px;">Research Assistant</div>
    <div style="font-size: 13px; color: #bbb;">T cell therapy, CAF targeting</div>
  </div>


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== 📄 Selected Publications ==
== 🔬 Research Areas ==


* **Wang Y**, et al. ''Infinite Molecular Networking: pH-Gated Peptide-DNA Chain Assembly for Death Receptor Activation.'' ''Nature Nanotechnology'', 2025.
<ul style="line-height: 1.7; padding-left: 20px;">
* **Xie G**, Wang Y. ''RNA Origami Logic Circuits for Controlled Immune Cell Activation.'' ''Science Advances'', 2024.
  <li><b>DNA/RNA Origami</b> – Engineering of 2D/3D nanostructures for targeted therapeutic delivery.</li>
* **Xu A**, et al. ''In Vivo Proximity Ligation Assay for Wireframe DNA Origami.'' ''ACS Nano'', 2024.
  <li><b>Logic-gated Immunotherapy</b> – Using aptamer switches and circuits for tumor-specific T cell activation.</li>
* **Wang Y**, Wu M-R. ''CAF-Targeted Aptamer-Antibody Cascades for Gated T Cell Engagement.'' ''Nature Biomedical Engineering'', 2024.
  <li><b>Receptor Clustering</b> – Peptide-DNA conjugates that assemble under tumor acidity to trigger apoptosis.</li>
</ul>


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== 🧭 Lab Highlights ==
== 📄 Selected Publications ==


* 🏆 NSFC-STINT International Collaboration Grant Awarded (2024–2027) 
<ul style="line-height: 1.7; padding-left: 20px;">
* ✈️ Academic visit to Sichuan University (Nov 2024) 
  <li><b>Wang Y</b> et al. <i>Infinite Molecular Networking</i>. Nature Nanotechnology, 2025. [<a href="#">PDF</a>]</li>
* 🔬 Ongoing: Tornado RNA circuits in CAR-T cells 
  <li><b>Xie G</b>, Wang Y. <i>RNA Logic Circuits</i>. Science Advances, 2024. [<a href="#">DOI</a>]</li>
* 🧬 Launch of LabWiki Platform (2025)
</ul>


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== 📞 Contact ==
== 📞 Contact ==


**Lab address**: Institute of Synthetic Biopharmaceutics 
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**Email**: yangwa@yourlab.org   
<b>Email:</b> yangwa@yourlab.org   
**Website**: [https://yangwalab.com yangwalab.com]  
<br><b>Website:</b> <a href="https://yangwalab.com">yangwalab.com</a>  
**GitHub**: [https://github.com/yangwa github.com/yangwa]
<br><b>Address:</b> Institute of Synthetic Biopharmaceutics
</div>


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📅 This page was last updated on '''{{CURRENTYEAR}}/{{CURRENTMONTH}}/{{CURRENTDAY}}'''.
🕘 Page last updated on '''{{CURRENTYEAR}}/{{CURRENTMONTH}}/{{CURRENTDAY}}'''
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Revision as of 00:00, 12 April 2025

👋 Welcome to the Lab of Synthetic Biopharmaceutics

We are an interdisciplinary team developing programmable molecular systems for immunotherapy and targeted delivery.

👥 Current Members

 <img src="https://via.placeholder.com/200" style="width: 160px; height: 160px; border-radius: 50%; object-fit: cover; margin-bottom: 12px;" />
Dr. Yang Wang
Principal Investigator
 <img src="https://via.placeholder.com/200" style="width: 160px; height: 160px; border-radius: 50%; object-fit: cover; margin-bottom: 12px;" />
Guangneng Xie
PhD Student


🔬 Research Areas

  • DNA/RNA Origami – Engineering of 2D/3D nanostructures for targeted therapeutic delivery.
  • Logic-gated Immunotherapy – Using aptamer switches and circuits for tumor-specific T cell activation.
  • Receptor Clustering – Peptide-DNA conjugates that assemble under tumor acidity to trigger apoptosis.

📄 Selected Publications

  • Wang Y et al. Infinite Molecular Networking. Nature Nanotechnology, 2025. [<a href="#">PDF</a>]
  • Xie G, Wang Y. RNA Logic Circuits. Science Advances, 2024. [<a href="#">DOI</a>]

📞 Contact

Email: yangwa@yourlab.org
Website: <a href="https://yangwalab.com">yangwalab.com</a>
Address: Institute of Synthetic Biopharmaceutics

🕘 Page last updated on 2025/07/3

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