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== 🧠 Research Focus ==
== 🧠 Research Focus ==
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  <summary style="font-weight: bold; font-size: 16px; padding: 6px 0;">🧬 1. DNA/RNA Origami for Therapy</summary>
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    We design 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with precise spatial control and responsiveness to tumor cues.
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<details style="margin-bottom: 16px;">
  <summary style="font-weight: bold; font-size: 16px; padding: 6px 0;">🧠 2. Logic-Gated Immune Activation</summary>
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    We engineer aptamer–antibody logic systems and RNA circuits that enable conditional T cell activation within immunosuppressive tumor environments.
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  <summary style="font-weight: bold; font-size: 16px; padding: 6px 0;">🔗 3. Peptide–DNA Conjugates for Receptor Clustering</summary>
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    We create pH-responsive peptide–DNA materials that self-assemble in acidic tumor microenvironments to cluster death receptors (e.g., TRAIL-R) and induce apoptosis.
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== 👩‍🔬 Lab Members ==
== 👩‍🔬 Lab Members ==

Revision as of 23:46, 11 April 2025

👋 Welcome to the Lab of Synthetic Biopharmaceutics

We are a multidisciplinary team working at the intersection of **synthetic biology**, **DNA/RNA nanotechnology**, and **targeted drug delivery**. Our mission is to develop programmable molecular systems for precision immunotherapy and intracellular control.

🧠 Research Focus

👩‍🔬 Lab Members

Dr. Yang Wang
Principal Investigator
DNA nanomedicine, synthetic biology
📧 yangwa@yourlab.org
Guangneng Xie
PhD Student
RNA origami, immune circuits
Anran Xu
PhD Student
DNA origami integrity, blood-based detection
Kang Wang
Research Assistant
T cell therapy, CAF targeting

📄 Selected Publications

  • **Wang Y**, et al. Infinite Molecular Networking: pH-Gated Peptide-DNA Chain Assembly for Death Receptor Activation. Nature Nanotechnology, 2025.
  • **Xie G**, Wang Y. RNA Origami Logic Circuits for Controlled Immune Cell Activation. Science Advances, 2024.
  • **Xu A**, et al. In Vivo Proximity Ligation Assay for Wireframe DNA Origami. ACS Nano, 2024.
  • **Wang Y**, Wu M-R. CAF-Targeted Aptamer-Antibody Cascades for Gated T Cell Engagement. Nature Biomedical Engineering, 2024.

🧭 Lab Highlights

  • 🏆 NSFC-STINT International Collaboration Grant Awarded (2024–2027)
  • ✈️ Academic visit to Sichuan University (Nov 2024)
  • 🔬 Ongoing: Tornado RNA circuits in CAR-T cells
  • 🧬 Launch of LabWiki Platform (2025)

📞 Contact

📅 This page was last updated on 2025/07/3.

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