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(Created page with "= 👋 Welcome to the Lab of Synthetic Biopharmaceutics = We are a multidisciplinary team working at the intersection of **synthetic biology**, **DNA/RNA nanotechnology**, and **targeted drug delivery**. Our mission is to develop programmable molecular systems for precision immunotherapy and intracellular control. ---- == 🔬 Research Focus == <details open> <summary style="font-weight: bold; font-size: 16px;">1️⃣ DNA/RNA Origami for Therapy</summary> Desi...")
 
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== 🔬 Research Focus ==
== 🔬 Research Focus ==


<details open>
<details open style="margin-bottom: 16px;">
   <summary style="font-weight: bold; font-size: 16px;">1️⃣ DNA/RNA Origami for Therapy</summary>
   <summary style="font-weight: bold; font-size: 16px; padding: 6px 0;">🧬 1. DNA/RNA Origami for Therapy</summary>
   Design of 2D and 3D nanostructures for delivering siRNA, aptamers, and proteins with spatial precision and responsiveness to tumor signals.
   <div style="margin-top: 8px; line-height: 1.6;">
    We design 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with precise spatial control and responsiveness to tumor cues.
  </div>
</details>
</details>


<details>
<details style="margin-bottom: 16px;">
   <summary style="font-weight: bold; font-size: 16px;">2️⃣ Logic-Gated Immune Activation</summary>
   <summary style="font-weight: bold; font-size: 16px; padding: 6px 0;">⚙️ 2. Logic-Gated Immune Activation</summary>
   Development of antibody-aptamer systems and synthetic RNA circuits for T cell activation only under tumor-specific conditions.
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    We engineer aptamer-antibody logic systems and RNA circuits that enable conditional T cell activation within immunosuppressive tumor environments.
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</details>
</details>


<details>
<details style="margin-bottom: 16px;">
   <summary style="font-weight: bold; font-size: 16px;">3️⃣ Peptide-DNA Conjugates for Receptor Clustering</summary>
   <summary style="font-weight: bold; font-size: 16px; padding: 6px 0;">🔗 3. Peptide–DNA Conjugates for Receptor Clustering</summary>
   Construction of self-assembling chains to activate death receptors (e.g., TRAIL-R) via pH-triggered ligand assembly in the tumor microenvironment.
   <div style="margin-top: 8px; line-height: 1.6;">
    We create pH-responsive peptide-DNA materials that self-assemble in acidic tumor microenvironments to cluster death receptors (e.g., TRAIL-R) and induce apoptosis.
  </div>
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</details>
----


== 👩‍🔬 Lab Members ==
== 👩‍🔬 Lab Members ==

Revision as of 23:40, 11 April 2025

👋 Welcome to the Lab of Synthetic Biopharmaceutics

We are a multidisciplinary team working at the intersection of **synthetic biology**, **DNA/RNA nanotechnology**, and **targeted drug delivery**. Our mission is to develop programmable molecular systems for precision immunotherapy and intracellular control.

🔬 Research Focus

<details open style="margin-bottom: 16px;"> 

 <summary style="font-weight: bold; font-size: 16px; padding: 6px 0;">🧬 1. DNA/RNA Origami for Therapy</summary>

   We design 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with precise spatial control and responsiveness to tumor cues.

</details>

<details style="margin-bottom: 16px;"> 

 <summary style="font-weight: bold; font-size: 16px; padding: 6px 0;">⚙️ 2. Logic-Gated Immune Activation</summary>

   We engineer aptamer-antibody logic systems and RNA circuits that enable conditional T cell activation within immunosuppressive tumor environments.

</details>

<details style="margin-bottom: 16px;"> 

 <summary style="font-weight: bold; font-size: 16px; padding: 6px 0;">🔗 3. Peptide–DNA Conjugates for Receptor Clustering</summary>

   We create pH-responsive peptide-DNA materials that self-assemble in acidic tumor microenvironments to cluster death receptors (e.g., TRAIL-R) and induce apoptosis.

</details>

👩‍🔬 Lab Members

Name Role Focus Area Contact
Dr. Yang Wang PI DNA nanomedicine, synthetic biology yangwa@yourlab.org
Guangneng Xie PhD Student RNA origami, immune circuits
Anran Xu PhD Student DNA origami integrity, blood-based detection
Kang Wang Research Assistant T cell therapy, CAF targeting

📚 Selected Publications

  • **Wang Y**, et al. Infinite Molecular Networking: pH-Gated Peptide-DNA Chain Assembly for Death Receptor Activation. *Nature Nanotechnology*, 2025.
  • **Xie G**, Wang Y. RNA Origami Logic Circuits for Controlled Immune Cell Activation. *Science Advances*, 2024.
  • **Xu A**, et al. In Vivo Proximity Ligation Assay for Wireframe DNA Origami. *ACS Nano*, 2024.
  • **Wang Y**, Wu M-R. CAF-Targeted Aptamer-Antibody Cascades for Gated T Cell Engagement. *Nature Biomedical Engineering*, 2024.

🧭 Lab Highlights

  • 🏆 NSFC-STINT International Collaboration Grant Awarded (2024–2027)
  • ✈️ Academic visit to Sichuan University (Nov 2024)
  • 🔬 Ongoing: Tornado RNA circuits in CAR-T cells
  • 🧬 Launch of LabWiki Platform (2025)

📞 Contact

📅 This page was last updated on 2025/07/3.

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