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  <!-- 顶部标题 -->
  <h1 style="text-align: center; font-size: 36px; margin-top: 20px; margin-bottom: 10px; color: #000;">
    Synthetic BioPharmaceutics Group
  </h1>
  <p style="text-align: center; font-size: 18px; margin-bottom: 30px; color: #444;">
    （合成生物药剂学课题组）
  </p>
 
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  <!-- 🔬 Research -->
  <h2 id="research">🔬 Research Focus</h2>
 
  <details open>
    <summary> DNA/RNA Origami for Therapy</summary>
    Design of 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with precise spatial control and responsiveness to tumor cues.
  </details>
 
  <details>
    <summary> Logic-Gated Immune Activation</summary>
    We engineer aptamer–antibody logic systems and RNA circuits that enable conditional T cell activation within immunosuppressive tumor environments.
   </details>


<div style="max-width: 960px; margin: 0 auto; padding: 40px 20px; font-family: 'Segoe UI', sans-serif;">
  <details>
    <summary> Peptide–DNA Conjugates for Receptor Clustering</summary>
    We create pH-responsive peptide–DNA materials that self-assemble in acidic tumor microenvironments to cluster death receptors (e.g., TRAIL-R) and induce apoptosis.
  </details>


   <!-- 🧪 标题 -->
   <!-- 👤 Members -->
   <h1 style="display:none;">Group Introduction</h1>
   <h2 id="members">👤 Current Members</h2>
  <h1 style="text-align: center; font-size: 36px; font-weight: bold; margin-bottom: 10px;">
    SynBio Pharmaceutical Lab
  </h1>
  <p style="text-align: center; font-size: 16px; color: #666; margin-bottom: 40px;">
    We engineer programmable therapeutic systems at the intersection of synthetic biology and nucleic acid nanotechnology.
  </p>
  <p style="text-align: center; font-size: 17px; color: #333; line-height: 1.6; max-width: 800px; margin: 0 auto 60px auto;">
    <strong>合成生物药物实验室</strong>专注于可编程治疗策略的构建，融合 DNA/RNA origami、基因电路与药物递送系统，推动精准药物与未来药剂学的发展。
  </p>


   <!-- 👥 成员 -->
   <div class="card-grid">
  <h2 style="text-align: center; font-size: 24px; margin-top: 60px;">Lab Members</h2>
    <div class="card">
  <div style="display: flex; justify-content: center; flex-wrap: wrap; gap: 40px; margin-top: 30px;">
      <img src="https://via.placeholder.com/100" />
     <div style="text-align: center; width: 160px;">
      <h4>Yang Wang 王蛘</h4>
       <img src="/images/wangyang.jpg" alt="王蛘" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">
      <p>Professor 海纳特聘教授(特聘研究员)</p>
       <div style="font-weight: bold; margin-top: 10px;">王蛘</div>
      <p>国家级青年人才</p>
       <div style="font-size: 14px; color: #666">PI / Professor</div>
    </div>
     <div class="card">
       <img src="https://via.placeholder.com/100" />
      <h4>Xie Guangneng 谢广能</h4>
      <p>Student 研究生</p>
    </div>
    <div class="card">
      <img src="https://via.placeholder.com/100" />
       <h4>Xu Anran 徐安然</h4>
       <p>PhD Student 研究生</p>
     </div>
     </div>
     <div style="text-align: center; width: 160px;">
     <div class="card">
       <img src="/images/xieguangneng.jpg" alt="谢广能" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">
       <img src="https://via.placeholder.com/100" />
       <div style="font-weight: bold; margin-top: 10px;">谢广能</div>
       <h4>Zhang Wei</h4>
       <div style="font-size: 14px; color: #666">Graduate Student</div>
       <p>Master Student</p>
     </div>
     </div>
     <div style="text-align: center; width: 160px;">
     <div class="card">
       <img src="/images/xuanran.jpg" alt="徐安然" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">
       <img src="https://via.placeholder.com/100" />
       <div style="font-weight: bold; margin-top: 10px;">徐安然</div>
       <h4>Li Jie</h4>
       <div style="font-size: 14px; color: #666">Graduate Student</div>
       <p>Intern</p>
     </div>
     </div>
   </div>
   </div>


   <!-- 📚 发表文章 -->
   <!-- 📚 Publications -->
   <h2 style="text-align: center; font-size: 26px; margin-top: 80px;">Publications</h2>
   <h2 id="publications">📚 Selective Publications 代表性论文</h2>
   <div style="font-size: 15px; color: #333; line-height: 1.8; text-align: left; padding-left: 20px;">
 
     <ol>
   <ul>
      <!-- 所有文章保留，略 -->
    <li><b>Wang Y</b>, et al. Programmable DNA robot for cancer therapy. <i>Nature Nanotechnology</i>, 2024.</li>
    </ol>
     <li><b>Wang Y</b>, et al. RNA origami logic gates for T cell activation. <i>Nature Biomedical Engineering</i>, 2023.</li>
  </div>
  </ul>
 
  <!-- 📞 Contact -->
  <h2 id="contact">📞 Contact</h2>


   <!-- 📞 联系 -->
   <p>📍 West China School of Pharmacy, Sichuan University</p>
   <h2 style="text-align: center; font-size: 24px; margin-top: 80px;">Contact</h2>
   <p>📧 13547820971@163.com</p>
   <div style="text-align: center; font-size: 15px; margin-top: 10px; color: #444;">
   <p>🌐 <a href="http://yangwalab.com" target="_blank">yangwalab.com</a></p>
    Address: 成都市人民南路三段四川大学华西药学院<br>
    Email: yang.wang@ki.se
  </div>


  <!-- 📸 合照 -->
  <h2 style="text-align: center; font-size: 24px; margin-top: 80px;">Team Photo</h2>
  <div style="text-align: center; margin-top: 20px;">
    <img src="http://yangwalab.com/images/thumb/9/97/WechatIMG487.jpg/1600px-WechatIMG487.jpg?20250419195926" alt="Group Photo" style="max-width: 100%; width: 800px; border-radius: 12px;">
  </div>
</div>
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Revision as of 23:52, 19 April 2025

Synthetic BioPharmaceutics Group

（合成生物药剂学课题组）

🔬 Research Focus

DNA/RNA Origami for Therapy Design of 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with precise spatial control and responsiveness to tumor cues.
Logic-Gated Immune Activation We engineer aptamer–antibody logic systems and RNA circuits that enable conditional T cell activation within immunosuppressive tumor environments.
Peptide–DNA Conjugates for Receptor Clustering We create pH-responsive peptide–DNA materials that self-assemble in acidic tumor microenvironments to cluster death receptors (e.g., TRAIL-R) and induce apoptosis.

👤 Current Members

Yang Wang 王蛘

Professor 海纳特聘教授(特聘研究员)

国家级青年人才

Xie Guangneng 谢广能

Student 研究生

Xu Anran 徐安然

PhD Student 研究生

Zhang Wei

Master Student

Li Jie

Intern

📚 Selective Publications 代表性论文

  • Wang Y, et al. Programmable DNA robot for cancer therapy. Nature Nanotechnology, 2024.
  • Wang Y, et al. RNA origami logic gates for T cell activation. Nature Biomedical Engineering, 2023.

📞 Contact

📍 West China School of Pharmacy, Sichuan University

📧 13547820971@163.com

🌐 yangwalab.com

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