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<summary> | <summary> DNA/RNA Origami for Therapy</summary> | ||
Design of 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with precise spatial control and responsiveness to tumor cues. | Design of 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with precise spatial control and responsiveness to tumor cues. | ||
</details> | </details> | ||
<details> | <details> | ||
<summary> | <summary> Logic-Gated Immune Activation</summary> | ||
We engineer aptamer–antibody logic systems and RNA circuits that enable conditional T cell activation within immunosuppressive tumor environments. | We engineer aptamer–antibody logic systems and RNA circuits that enable conditional T cell activation within immunosuppressive tumor environments. | ||
</details> | </details> | ||
<details> | <details> | ||
<summary> | <summary> Peptide–DNA Conjugates for Receptor Clustering</summary> | ||
We create pH-responsive peptide–DNA materials that self-assemble in acidic tumor microenvironments to cluster death receptors (e.g., TRAIL-R) and induce apoptosis. | We create pH-responsive peptide–DNA materials that self-assemble in acidic tumor microenvironments to cluster death receptors (e.g., TRAIL-R) and induce apoptosis. | ||
</details> | </details> | ||
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<div class="card-grid"> | <div class="card-grid"> | ||
<div class="card"> | <div class="card"> | ||
<img src="https://via.placeholder.com/ | <img src="https://via.placeholder.com/100" /> | ||
<h4>Yang Wang</h4> | <h4>Yang Wang</h4> | ||
<p> | <p>PI</p> | ||
</div> | </div> | ||
<div class="card"> | <div class="card"> | ||
<img src="https://via.placeholder.com/ | <img src="https://via.placeholder.com/100" /> | ||
<h4>Xie Guangneng</h4> | <h4>Xie Guangneng</h4> | ||
<p>PhD Student</p> | <p>PhD Student</p> | ||
</div> | </div> | ||
<div class="card"> | <div class="card"> | ||
<img src="https://via.placeholder.com/ | <img src="https://via.placeholder.com/100" /> | ||
<h4>Xu Anran</h4> | <h4>Xu Anran</h4> | ||
<p>PhD Student</p> | <p>PhD Student</p> | ||
</div> | |||
<div class="card"> | |||
<img src="https://via.placeholder.com/100" /> | |||
<h4>Zhang Wei</h4> | |||
<p>Master Student</p> | |||
</div> | |||
<div class="card"> | |||
<img src="https://via.placeholder.com/100" /> | |||
<h4>Li Jie</h4> | |||
<p>Intern</p> | |||
</div> | </div> | ||
</div> | </div> | ||
Revision as of 03:24, 12 April 2025
Research Focus
DNA/RNA Origami for Therapy
Design of 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with precise spatial control and responsiveness to tumor cues.Logic-Gated Immune Activation
We engineer aptamer–antibody logic systems and RNA circuits that enable conditional T cell activation within immunosuppressive tumor environments.Peptide–DNA Conjugates for Receptor Clustering
We create pH-responsive peptide–DNA materials that self-assemble in acidic tumor microenvironments to cluster death receptors (e.g., TRAIL-R) and induce apoptosis.Current Members
Yang Wang
PI
Xie Guangneng
PhD Student
Xu Anran
PhD Student
Zhang Wei
Master Student
Li Jie
Intern
Publications
- Wang Y, et al. Programmable DNA robot for cancer therapy. Nature Nanotechnology, 2024.
- Wang Y, et al. RNA origami logic gates for T cell activation. Nature Biomedical Engineering, 2023.
Contact
📍 West China School of Pharmacy, Sichuan University
📧 yangwa@lab.edu