Yangwa:GroupIntro: Difference between revisions

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Line 3: Line 3:
     body {
     body {
       font-family: 'Segoe UI', sans-serif;
       font-family: 'Segoe UI', sans-serif;
       background-color: white;
       background-color: #0a0a0a;
       color: #000000;
       color: #f0f0f0;
     }
     }


Line 13: Line 13:
       align-items: center;
       align-items: center;
       gap: 10px;
       gap: 10px;
       color: #000000;
       color: #ffffff;
     }
     }


Line 21: Line 21:


     details {
     details {
       background: #f9f9f9;
       background: #1a1a1a;
       border: 1px solid #ccc;
       border: 1px solid #444;
       border-radius: 8px;
       border-radius: 8px;
       padding: 14px 20px;
       padding: 14px 20px;
Line 32: Line 32:
       font-weight: bold;
       font-weight: bold;
       padding: 6px 0;
       padding: 6px 0;
       color: #000000;
       color: #ffffff;
     }
     }


Line 44: Line 44:
     .card {
     .card {
       flex: 1 1 240px;
       flex: 1 1 240px;
       border: 1px solid #ddd;
       border: 1px solid #333;
       border-radius: 12px;
       border-radius: 12px;
       padding: 16px;
       padding: 16px;
       background: #ffffff;
       background: #1c1c1c;
       text-align: center;
       text-align: center;
       box-shadow: 0 2px 6px rgba(0,0,0,0.05);
       box-shadow: 0 2px 6px rgba(0,0,0,0.2);
     }
     }


Line 58: Line 58:
       object-fit: cover;
       object-fit: cover;
       margin-bottom: 12px;
       margin-bottom: 12px;
      border: 2px solid #666;
     }
     }


Line 63: Line 64:
       font-size: 18px;
       font-size: 18px;
       margin-bottom: 4px;
       margin-bottom: 4px;
       color: #000000;
       color: #ffffff;
     }
     }


     .card p {
     .card p {
       font-size: 14px;
       font-size: 14px;
       color: #000000;
       color: #cccccc;
     }
     }


     a {
     a {
       color: #007BFF;
       color: #66ccff;
       text-decoration: none;
       text-decoration: none;
     }
     }


     a:hover {
     a:hover {
      color: #88ddff;
       text-decoration: underline;
       text-decoration: underline;
    }
    ul li {
      margin-bottom: 8px;
     }
     }
   </style>
   </style>

Revision as of 03:20, 12 April 2025

Research Focus

🔬 DNA/RNA Origami for Therapy Design of 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with precise spatial control and responsiveness to tumor cues.
🧠 Logic-Gated Immune Activation We engineer aptamer–antibody logic systems and RNA circuits that enable conditional T cell activation within immunosuppressive tumor environments.
🧬 Peptide–DNA Conjugates for Receptor Clustering We create pH-responsive peptide–DNA materials that self-assemble in acidic tumor microenvironments to cluster death receptors (e.g., TRAIL-R) and induce apoptosis.

Current Members

Yang Wang

Principal Investigator

Xie Guangneng

PhD Student

Xu Anran

PhD Student

Publications

  • Wang Y, et al. Programmable DNA robot for cancer therapy. Nature Nanotechnology, 2024.
  • Wang Y, et al. RNA origami logic gates for T cell activation. Nature Biomedical Engineering, 2023.

Contact

📍 West China School of Pharmacy, Sichuan University

📧 yangwa@lab.edu

🌐 yangwalab.com