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<!-- 👋 Introduction -->
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  <h2>🧬 About Our Lab</h2>
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     We are a synthetic biology lab focusing on programmable molecular systems for precision immunotherapy and intracellular control.
    Our mission is to engineer intelligent biomaterials and RNA circuits to reprogram cellular functions in disease contexts.
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<!-- 🎯 Research -->
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   <h2>🔬 Research Focus</h2>
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   <h2>Research Focus</h2>
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      <h3>1. DNA/RNA Origami for Therapy</h3>
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    <summary>🔬 DNA/RNA Origami for Therapy</summary>
        Design of 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with spatial precision and responsiveness to tumor cues.
    Design of 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with precise spatial control and responsiveness to tumor cues.
      </p>
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  <details>
      <h3>2. Logic-Gated Immune Activation</h3>
     <summary>🧠 Logic-Gated Immune Activation</summary>
      <p>
    We engineer aptamer–antibody logic systems and RNA circuits that enable conditional T cell activation within immunosuppressive tumor environments.
        Development of antibody–aptamer systems and synthetic RNA circuits for T cell activation only under tumor-specific conditions.
  </details>
      </p>
 
    </div>
  <details>
     <div class="card">
     <summary>🧬 Peptide–DNA Conjugates for Receptor Clustering</summary>
      <h3>3. Peptide–DNA Conjugates</h3>
    We create pH-responsive peptide–DNA materials that self-assemble in acidic tumor microenvironments to cluster death receptors (e.g., TRAIL-R) and induce apoptosis.
      <p>
  </details>
        Construction of self-assembling chains to cluster death receptors (e.g., TRAIL-R) via pH-triggered ligand assembly in the tumor microenvironment.
 
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   <h2>Current Members</h2>
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  <h2>👥 Current Members</h2>
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       <h3>Yang Wang, PhD</h3>
       <img src="https://via.placeholder.com/120" />
      <h4>Yang Wang</h4>
       <p>Principal Investigator</p>
       <p>Principal Investigator</p>
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       <h3>Guangneng Xie</h3>
       <img src="https://via.placeholder.com/120" />
       <p>Master Student</p>
      <h4>Xie Guangneng</h4>
       <p>PhD Student</p>
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       <h3>Anran Xu</h3>
       <img src="https://via.placeholder.com/120" />
       <p>Master Student</p>
      <h4>Xu Anran</h4>
       <p>PhD Student</p>
     </div>
     </div>
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<!-- 📚 Publications -->
   <h2>Publications</h2>
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   <h2>📚 Selected Publications</h2>
   <ul>
   <ul>
     <li>Wang Y et al. *Aptamer logic-guided T cell activation in pancreatic cancer*. Nature Biotech, 2025.</li>
     <li><b>Wang Y</b>, et al. Programmable DNA robot for cancer therapy. <i>Nature Nanotechnology</i>, 2024.</li>
     <li>Wang Y et al. *pH-programmable peptide-DNA nanostructures for apoptosis induction*. Nature Nanotechnology, 2024.</li>
     <li><b>Wang Y</b>, et al. RNA origami logic gates for T cell activation. <i>Nature Biomedical Engineering</i>, 2023.</li>
   </ul>
   </ul>
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<!-- 📞 Contact -->
   <h2>Contact</h2>
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   <h2>📞 Contact</h2>
   <p>📍 West China School of Pharmacy, Sichuan University</p>
   <p>📍 West China School of Pharmacy, Sichuan University</p>
   <p>✉️ yangwa@lab.edu</p>
   <p>📧 yangwa@lab.edu</p>
   <p>🌐 <a href="http://yangwalab.com" target="_blank">yangwalab.com</a></p>
   <p>🌐 <a href="http://yangwalab.com" target="_blank">yangwalab.com</a></p>
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Revision as of 03:18, 12 April 2025

Research Focus

🔬 DNA/RNA Origami for Therapy Design of 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with precise spatial control and responsiveness to tumor cues.
🧠 Logic-Gated Immune Activation We engineer aptamer–antibody logic systems and RNA circuits that enable conditional T cell activation within immunosuppressive tumor environments.
🧬 Peptide–DNA Conjugates for Receptor Clustering We create pH-responsive peptide–DNA materials that self-assemble in acidic tumor microenvironments to cluster death receptors (e.g., TRAIL-R) and induce apoptosis.

Current Members

Yang Wang

Principal Investigator

Xie Guangneng

PhD Student

Xu Anran

PhD Student

Publications

  • Wang Y, et al. Programmable DNA robot for cancer therapy. Nature Nanotechnology, 2024.
  • Wang Y, et al. RNA origami logic gates for T cell activation. Nature Biomedical Engineering, 2023.

Contact

📍 West China School of Pharmacy, Sichuan University

📧 yangwa@lab.edu

🌐 yangwalab.com

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