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   <h2 style="font-size: 28px; margin-bottom: 12px;">🧬 Lab Introduction</h2>
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    The Lab of Synthetic Biopharmaceutics is dedicated to engineering DNA/RNA-based nanostructures and logic-gated therapeutic platforms for precision medicine. Our research spans synthetic biology, cancer immunotherapy, and molecular programming. We aim to build programmable systems that bridge molecular sensing and disease targeting.
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  <h2>🧬 About Our Lab</h2>
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    We are a synthetic biology lab focusing on programmable molecular systems for precision immunotherapy and intracellular control.
    Our mission is to engineer intelligent biomaterials and RNA circuits to reprogram cellular functions in disease contexts.
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  <h2 style="font-size: 28px; margin-top: 48px; margin-bottom: 24px;">👥 Team Members</h2>
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  <h2>🔬 Research Focus</h2>


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      <div style="font-weight: bold;">Dr. Yang Wang</div>
      <h3>1. DNA/RNA Origami for Therapy</h3>
       <div style="font-size: 14px; color: #555;">Principal Investigator</div>
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        Design of 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with spatial precision and responsiveness to tumor cues.
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      <h3>2. Logic-Gated Immune Activation</h3>
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        Development of antibody–aptamer systems and synthetic RNA circuits for T cell activation only under tumor-specific conditions.
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      <h3>3. Peptide–DNA Conjugates</h3>
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        Construction of self-assembling chains to cluster death receptors (e.g., TRAIL-R) via pH-triggered ligand assembly in the tumor microenvironment.
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      <div style="font-weight: bold;">谢广能</div>
  <h2>👥 Current Members</h2>
      <div style="font-size: 14px; color: #555;">PhD Student</div>
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      <h3>Yang Wang, PhD</h3>
      <p>Principal Investigator</p>
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      <h3>Guangneng Xie</h3>
      <p>Master Student</p>
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       <h3>Anran Xu</h3>
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       <p>Master Student</p>
      <div style="font-weight: bold;">徐安然</div>
       <div style="font-size: 14px; color: #555;">PhD Student</div>
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  <h2 style="font-size: 28px; margin-top: 48px; margin-bottom: 12px;">📚 Selected Publications</h2>
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  <h2>📚 Selected Publications</h2>
     <li>Wang Y et al. <i>Nanorobots for acid-triggered TME targeting</i>. <b>Nature Nanotechnology</b>, 2024.</li>
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    <li>Wang Y et al. <i>RNA circuits for T cell logic activation in PDAC</i>. <b>Nature Biotechnology</b>, 2023.</li>
     <li>Wang Y et al. *Aptamer logic-guided T cell activation in pancreatic cancer*. Nature Biotech, 2025.</li>
     <li>Wang Y et al. <i>DNA origami vaccine carriers crossing the BBB</i>. <b>Advanced Materials</b>, 2023.</li>
     <li>Wang Y et al. *pH-programmable peptide-DNA nanostructures for apoptosis induction*. Nature Nanotechnology, 2024.</li>
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  <h2>📞 Contact</h2>
    📍 West China School of Pharmacy, Sichuan University<br>
   <p>📍 West China School of Pharmacy, Sichuan University</p>
    ✉️ yangwa@lab.edu<br>
  <p>✉️ yangwa@lab.edu</p>
    🌐 <a href="http://yangwalab.com" target="_blank" style="color: #007BFF;">yangwalab.com</a>
  <p>🌐 <a href="http://yangwalab.com" target="_blank">yangwalab.com</a></p>
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Revision as of 03:17, 12 April 2025

🧬 About Our Lab

We are a synthetic biology lab focusing on programmable molecular systems for precision immunotherapy and intracellular control. Our mission is to engineer intelligent biomaterials and RNA circuits to reprogram cellular functions in disease contexts.

🔬 Research Focus

1. DNA/RNA Origami for Therapy

Design of 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with spatial precision and responsiveness to tumor cues.

2. Logic-Gated Immune Activation

Development of antibody–aptamer systems and synthetic RNA circuits for T cell activation only under tumor-specific conditions.

3. Peptide–DNA Conjugates

Construction of self-assembling chains to cluster death receptors (e.g., TRAIL-R) via pH-triggered ligand assembly in the tumor microenvironment.

👥 Current Members

Yang Wang, PhD

Principal Investigator

Guangneng Xie

Master Student

Anran Xu

Master Student

📚 Selected Publications

  • Wang Y et al. *Aptamer logic-guided T cell activation in pancreatic cancer*. Nature Biotech, 2025.
  • Wang Y et al. *pH-programmable peptide-DNA nanostructures for apoptosis induction*. Nature Nanotechnology, 2024.

📞 Contact

📍 West China School of Pharmacy, Sichuan University

✉️ yangwa@lab.edu

🌐 yangwalab.com

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