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= 👋 Welcome to the Lab of Synthetic Biopharmaceutics =
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We are a multidisciplinary team working at the intersection of **synthetic biology**, **DNA/RNA nanotechnology**, and **targeted drug delivery**. 
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Our mission is to develop programmable molecular systems for precision immunotherapy and intracellular control.


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== 🧠 Research Focus ==
<div style="max-width: 960px; margin: 0 auto; padding: 40px 20px; font-family: 'Segoe UI', sans-serif;">


<details open style="margin-bottom: 16px;">
  <!-- 🧪 标题 -->
   <summary style="font-weight: bold; font-size: 16px; padding: 6px 0;">🧬 1. DNA/RNA Origami for Therapy</summary>
   <h1 style="display:none;">Group Introduction</h1>
   <div style="margin-top: 8px; line-height: 1.6; font-size: 15px;">
   <h1 style="text-align: center; font-size: 36px; font-weight: bold; margin-bottom: 10px;">
     We design 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with precise spatial control and responsiveness to tumor cues.
     SynBio Pharmaceutical Lab
   </div>
   </h1>
</details>
   <p style="text-align: center; font-size: 16px; color: #666; margin-bottom: 40px;">
 
    We engineer programmable therapeutic systems at the intersection of synthetic biology and nucleic acid nanotechnology.
<details style="margin-bottom: 16px;">
  </p>
   <summary style="font-weight: bold; font-size: 16px; padding: 6px 0;">🧠 2. Logic-Gated Immune Activation</summary>
   <p style="text-align: center; font-size: 17px; color: #333; line-height: 1.6; max-width: 800px; margin: 0 auto 60px auto;">
   <div style="margin-top: 8px; line-height: 1.6; font-size: 15px;">
     <strong>合成生物药物实验室</strong>专注于可编程治疗策略的构建，融合 DNA/RNA origami、基因电路与药物递送系统，推动精准药物与未来药剂学的发展。
     We engineer aptamer–antibody logic systems and RNA circuits that enable conditional T cell activation within immunosuppressive tumor environments.
  </p>
  </div>
</details>


<details style="margin-bottom: 16px;">
  <!-- 👥 成员 -->
   <summary style="font-weight: bold; font-size: 16px; padding: 6px 0;">🔗 3. Peptide–DNA Conjugates for Receptor Clustering</summary>
  <h2 style="text-align: center; font-size: 24px; margin-top: 60px;">Lab Members</h2>
  <div style="margin-top: 8px; line-height: 1.6; font-size: 15px;">
   <div style="display: flex; justify-content: center; flex-wrap: wrap; gap: 40px; margin-top: 30px;">
     We create pH-responsive peptide–DNA materials that self-assemble in acidic tumor microenvironments to cluster death receptors (e.g., TRAIL-R) and induce apoptosis.
    <div style="text-align: center; width: 160px;">
      <img src="/images/wangyang.jpg" alt="王蛘" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">
      <div style="font-weight: bold; margin-top: 10px;">王蛘</div>
      <div style="font-size: 14px; color: #666">PI / Professor</div>
    </div>
    <div style="text-align: center; width: 160px;">
      <img src="/images/xieguangneng.jpg" alt="谢广能" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">
      <div style="font-weight: bold; margin-top: 10px;">谢广能</div>
      <div style="font-size: 14px; color: #666">Graduate Student</div>
    </div>
    <div style="text-align: center; width: 160px;">
      <img src="/images/xuanran.jpg" alt="徐安然" style="width: 120px; height: 120px; border-radius: 50%; object-fit: cover;">
      <div style="font-weight: bold; margin-top: 10px;">徐安然</div>
      <div style="font-size: 14px; color: #666">Graduate Student</div>
     </div>
   </div>
   </div>
</details>
----


== 👩‍🔬 Lab Members ==
  <!-- 📚 发表文章 -->
 
  <h2 style="text-align: center; font-size: 26px; margin-top: 80px;">Publications</h2>
<div style="display: flex; flex-wrap: wrap; gap: 20px; justify-content: flex-start; margin-top: 16px;">
   <div style="font-size: 15px; color: #333; line-height: 1.8; text-align: left; padding-left: 20px;">
 
    <ol>
   <!-- PI -->
      <li><span style="text-decoration: underline;">Wang Yang</span>, Igor Baars, Ieva Berzina, Iris Rocamonde-Lago, Boxuan Shen, Yunshi Yang, Marco Lolaico, Janine Waldvogel, Ioanna Smyrlaki, Keying Zhu, Robert A Harris, Björn Högberg*. <strong>A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns</strong>. <em style="color: #007BFF;">Nature Nanotechnology</em>. 19, 1366–1374 (2024)</li>
  <div style="background-color: #1e1e1e; border: 1px solid #444; border-radius: 12px; padding: 16px; width: 280px; color: #eee; box-shadow: 0 2px 6px rgba(0,0,0,0.2);">
      <li>Ioanna Smyrlaki, Ferenc Fördős, Iris Rocamonde-Lago, <span style="text-decoration: underline;">Wang Yang</span>, Boxuan Shen, Antonio Lentini, Vincent C Luca, Björn Reinius, Ana I Teixeira, Björn Högberg*. <strong>Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force</strong>. <em style="color: #007BFF;">Nature Communications</em>. 15, 465 (2024)</li>
    <div style="font-weight: bold; font-size: 18px; margin-bottom: 6px;">Dr. Yang Wang</div>
      <li>Marco Lolaico, Sebbe Blokhuizen, Boxuan Shen, <span style="text-decoration: underline;">Wang Yang</span>, Björn Högberg*. <strong>Computer-Aided Design of A-Trail Routed Wireframe DNA Nanostructures with Square Lattice Edges</strong>. <em style="color: #007BFF;">ACS Nano</em>. 17, 6565–6574 (2023)</li>
    <div style="font-size: 14px; margin-bottom: 6px;">Principal Investigator</div>
      <li>Miao Deng, Rong Guo, <span style="text-decoration: underline;">Wang Yang</span>, Jia-Xin Li, Jiao He, Man Li*, and Qin He*. <strong>Curbing Exosome Communications via Introducing Artificial Membrane Receptors for Metastatic Pancreatic Cancer Therapy</strong>. <em style="color: #007BFF;">Advanced Materials</em>. 35, 2303736 (2023)</li>
    <div style="font-size: 13px; color: #bbb;">DNA nanomedicine, synthetic biology</div>
      <li>Jiaye Liu#, <span style="text-decoration: underline;">Wang Yang</span>#(co-first), Chunyang Mu#, Meng Li, Kewei Li, Shan Li, Wenshuang Wu, Lingyao Du, Xiaoyun Zhang, Chuan Li, Wei Peng, Junyi Shen, Yang Liu, Dujiang Yang, Kaixiang Zhang, Qingyang Ning, Xiaoying Fu, Yu Zeng, Yinyun Ni, Zongguang Zhou, Yi Liu, Yiguo Hu, Xiaofeng Zheng*, Tianfu Wen*, Zhihui Li*, Yong Liu*. <strong>Pancreatic tumor eradication via selective Pin1 inhibition in CAFs and T cells</strong>. <em style="color: #007BFF;">Nature Communications</em>. 13, 4308 (2022)</li>
    <div style="font-size: 13px; margin-top: 8px;">📧 yangwa@yourlab.org</div>
      <li>Keying Zhu, <span style="text-decoration: underline;">Wang Yang</span>, Heela Sarlus, Keyi Geng, Erik Nutma, Jingxian Sun, Shin‐Yu Kung, Cindy Bay, Jinming Han, Jin‐Hong Min, Irene Benito‐Cuesta, Harald Lund, Sandra Amor, Jun Wang, Xing‐Mei Zhang, Claudia Kutter, André Ortlieb Guerreiro‐Cacais, Björn Högberg, Robert A Harris*. <strong>Myeloid cell‐specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation</strong>. <em style="color: #007BFF;">EMBO Reports</em>. 23: e54499 (2022)</li>
      <li><span style="text-decoration: underline;">Wang Yang</span>, Erik Benson, Ferenc Fördős, Marco Lolaico, Igor Baars, Trixy Fang, Ana I Teixeira, Björn Högberg*. <strong>DNA Origami Penetration in Cell Spheroid Tissue Models is Enhanced by Wireframe Design</strong>. <em style="color: #007BFF;">Advanced Materials</em>. 33, 2008457 (2021)</li>
      <li><span style="text-decoration: underline;">Wang Yang</span>, Igor Baars, Ferenc Fördős, Björn Högberg*. <strong>Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides</strong>. <em style="color: #007BFF;">ACS Nano</em>. 15, 9614–9626 (2021)</li>
      <li>Toon Verheyen, Trixy Fang, Dominik Lindenhofer, <span style="text-decoration: underline;">Wang Yang</span>, Karen Akopyan, Arne Lindqvist, Björn Högberg, Ana I Teixeira*. <strong>Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers</strong>. <em style="color: #007BFF;">Nucleic Acid Research</em>. 48, 5777–5787 (2020)</li>
    </ol>
   </div>
   </div>


   <!-- Student 1 -->
   <!-- 📞 联系 -->
   <div style="background-color: #1e1e1e; border: 1px solid #444; border-radius: 12px; padding: 16px; width: 280px; color: #eee; box-shadow: 0 2px 6px rgba(0,0,0,0.2);">
   <h2 style="text-align: center; font-size: 24px; margin-top: 80px;">Contact</h2>
    <div style="font-weight: bold; font-size: 18px; margin-bottom: 6px;">Guangneng Xie</div>
  <div style="text-align: center; font-size: 15px; margin-top: 10px; color: #444;">
    <div style="font-size: 14px; margin-bottom: 6px;">PhD Student</div>
    Address: 成都市人民南路三段四川大学华西药学院<br>
    <div style="font-size: 13px; color: #bbb;">RNA origami, immune circuits</div>
    Email: yang.wang@ki.se
   </div>
   </div>


   <!-- Student 2 -->
   <!-- 📸 合照 -->
   <div style="background-color: #1e1e1e; border: 1px solid #444; border-radius: 12px; padding: 16px; width: 280px; color: #eee; box-shadow: 0 2px 6px rgba(0,0,0,0.2);">
   <h2 style="text-align: center; font-size: 24px; margin-top: 80px;">Team Photo</h2>
    <div style="font-weight: bold; font-size: 18px; margin-bottom: 6px;">Anran Xu</div>
  <div style="text-align: center; margin-top: 20px;">
    <div style="font-size: 14px; margin-bottom: 6px;">PhD Student</div>
     <img src="http://yangwalab.com/images/thumb/9/97/WechatIMG487.jpg/1600px-WechatIMG487.jpg?20250419195926" alt="Group Photo" style="max-width: 100%; width: 800px; border-radius: 12px;">
     <div style="font-size: 13px; color: #bbb;">DNA origami integrity, blood-based detection</div>
   </div>
   </div>
  <!-- RA -->
  <div style="background-color: #1e1e1e; border: 1px solid #444; border-radius: 12px; padding: 16px; width: 280px; color: #eee; box-shadow: 0 2px 6px rgba(0,0,0,0.2);">
    <div style="font-weight: bold; font-size: 18px; margin-bottom: 6px;">Kang Wang</div>
    <div style="font-size: 14px; margin-bottom: 6px;">Research Assistant</div>
    <div style="font-size: 13px; color: #bbb;">T cell therapy, CAF targeting</div>
  </div>
</div>
----
== 📄 Selected Publications ==
* **Wang Y**, et al. ''Infinite Molecular Networking: pH-Gated Peptide-DNA Chain Assembly for Death Receptor Activation.'' ''Nature Nanotechnology'', 2025.
* **Xie G**, Wang Y. ''RNA Origami Logic Circuits for Controlled Immune Cell Activation.'' ''Science Advances'', 2024.
* **Xu A**, et al. ''In Vivo Proximity Ligation Assay for Wireframe DNA Origami.'' ''ACS Nano'', 2024.
* **Wang Y**, Wu M-R. ''CAF-Targeted Aptamer-Antibody Cascades for Gated T Cell Engagement.'' ''Nature Biomedical Engineering'', 2024.
----
== 🧭 Lab Highlights ==
* 🏆 NSFC-STINT International Collaboration Grant Awarded (2024–2027) 
* ✈️ Academic visit to Sichuan University (Nov 2024) 
* 🔬 Ongoing: Tornado RNA circuits in CAR-T cells 
* 🧬 Launch of LabWiki Platform (2025)
----
== 📞 Contact ==
**Lab address**: Institute of Synthetic Biopharmaceutics 
**Email**: yangwa@yourlab.org 
**Website**: [https://yangwalab.com yangwalab.com] 
**GitHub**: [https://github.com/yangwa github.com/yangwa]
----
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📅 This page was last updated on '''{{CURRENTYEAR}}/{{CURRENTMONTH}}/{{CURRENTDAY}}'''.
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Latest revision as of 23:54, 19 April 2025


Group Introduction

SynBio Pharmaceutical Lab

We engineer programmable therapeutic systems at the intersection of synthetic biology and nucleic acid nanotechnology.

合成生物药物实验室专注于可编程治疗策略的构建，融合 DNA/RNA origami、基因电路与药物递送系统，推动精准药物与未来药剂学的发展。

Lab Members

王蛘
王蛘
PI / Professor
谢广能
谢广能
Graduate Student
徐安然
徐安然
Graduate Student

Publications

  1. Wang Yang, Igor Baars, Ieva Berzina, Iris Rocamonde-Lago, Boxuan Shen, Yunshi Yang, Marco Lolaico, Janine Waldvogel, Ioanna Smyrlaki, Keying Zhu, Robert A Harris, Björn Högberg*. A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns. Nature Nanotechnology. 19, 1366–1374 (2024)
  2. Ioanna Smyrlaki, Ferenc Fördős, Iris Rocamonde-Lago, Wang Yang, Boxuan Shen, Antonio Lentini, Vincent C Luca, Björn Reinius, Ana I Teixeira, Björn Högberg*. Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force. Nature Communications. 15, 465 (2024)
  3. Marco Lolaico, Sebbe Blokhuizen, Boxuan Shen, Wang Yang, Björn Högberg*. Computer-Aided Design of A-Trail Routed Wireframe DNA Nanostructures with Square Lattice Edges. ACS Nano. 17, 6565–6574 (2023)
  4. Miao Deng, Rong Guo, Wang Yang, Jia-Xin Li, Jiao He, Man Li*, and Qin He*. Curbing Exosome Communications via Introducing Artificial Membrane Receptors for Metastatic Pancreatic Cancer Therapy. Advanced Materials. 35, 2303736 (2023)
  5. Jiaye Liu#, Wang Yang#(co-first), Chunyang Mu#, Meng Li, Kewei Li, Shan Li, Wenshuang Wu, Lingyao Du, Xiaoyun Zhang, Chuan Li, Wei Peng, Junyi Shen, Yang Liu, Dujiang Yang, Kaixiang Zhang, Qingyang Ning, Xiaoying Fu, Yu Zeng, Yinyun Ni, Zongguang Zhou, Yi Liu, Yiguo Hu, Xiaofeng Zheng*, Tianfu Wen*, Zhihui Li*, Yong Liu*. Pancreatic tumor eradication via selective Pin1 inhibition in CAFs and T cells. Nature Communications. 13, 4308 (2022)
  6. Keying Zhu, Wang Yang, Heela Sarlus, Keyi Geng, Erik Nutma, Jingxian Sun, Shin‐Yu Kung, Cindy Bay, Jinming Han, Jin‐Hong Min, Irene Benito‐Cuesta, Harald Lund, Sandra Amor, Jun Wang, Xing‐Mei Zhang, Claudia Kutter, André Ortlieb Guerreiro‐Cacais, Björn Högberg, Robert A Harris*. Myeloid cell‐specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation. EMBO Reports. 23: e54499 (2022)
  7. Wang Yang, Erik Benson, Ferenc Fördős, Marco Lolaico, Igor Baars, Trixy Fang, Ana I Teixeira, Björn Högberg*. DNA Origami Penetration in Cell Spheroid Tissue Models is Enhanced by Wireframe Design. Advanced Materials. 33, 2008457 (2021)
  8. Wang Yang, Igor Baars, Ferenc Fördős, Björn Högberg*. Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides. ACS Nano. 15, 9614–9626 (2021)
  9. Toon Verheyen, Trixy Fang, Dominik Lindenhofer, Wang Yang, Karen Akopyan, Arne Lindqvist, Björn Högberg, Ana I Teixeira*. Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers. Nucleic Acid Research. 48, 5777–5787 (2020)

Contact

Address: 成都市人民南路三段四川大学华西药学院
Email: yang.wang@ki.se

Team Photo

Group Photo

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