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   <!-- 顶部标题 -->
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   <h1 style="text-align: center; font-size: 36px; margin-top: 20px; margin-bottom: 10px; color: #000;">
  <h1 style="display:none;">Group Introduction</h1>
     Synthetic BioPharmaceutics Group
   <h1 style="text-align: center; font-size: 36px; font-weight: bold; margin-bottom: 10px;">
     SynBio Pharmaceutical Lab 合成生物药物实验室
   </h1>
   </h1>
   <p style="text-align: center; font-size: 18px; margin-bottom: 30px; color: #444;">
   <p style="text-align: center; font-size: 16px; color: #666; margin-bottom: 40px;">
     （合成生物药剂学课题组）
    We engineer programmable therapeutic systems at the intersection of synthetic biology and nucleic acid nanotechnology.
  </p>
  <p style="text-align: center; font-size: 17px; color: #333; line-height: 1.6; max-width: 800px; margin: 0 auto 60px auto;">
     <strong>合成生物药物实验室</strong>专注三方面研究: 1)核酸折纸结构的设计与功能化，及其在药剂学中的纳米药物应用; 2)基于人工智能的合成生物学策略在免疫治疗中的应用探索; 3)合成细胞的构建与调控，及其在生物药剂学中的创新转化应用
   </p>
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   <style>
   <!-- 👥 成员 -->
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  <h2 style="text-align: center; font-size: 24px; margin-top: 60px;">Lab Members 课题组成员</h2>
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       <img src="http://yangwalab.com/images/a/ac/Yang_head_photo.jpg?20250420025754" alt="王蛘" style="width: 120px; height: auto; border-radius: 0;">
    }
       <div style="font-weight: bold; margin-top: 10px;color: #000;">王蛘</div>
 
      <div style="font-size: 14px; color: #666">四川大学华西药学院特聘研究员，博士生导师; 国家自然科学基金优秀青年科学基金项目（海外）</div>
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  <!-- 🔬 Research -->
  <h2 id="research">🔬 Research Focus</h2>
 
  <details open>
    <summary> DNA/RNA Origami for Therapy</summary>
    Design of 2D and 3D DNA/RNA nanostructures to deliver siRNA, aptamers, and proteins with precise spatial control and responsiveness to tumor cues.
  </details>
 
  <details>
    <summary> Logic-Gated Immune Activation</summary>
    We engineer aptamer–antibody logic systems and RNA circuits that enable conditional T cell activation within immunosuppressive tumor environments.
  </details>
 
  <details>
    <summary> Peptide–DNA Conjugates for Receptor Clustering</summary>
    We create pH-responsive peptide–DNA materials that self-assemble in acidic tumor microenvironments to cluster death receptors (e.g., TRAIL-R) and induce apoptosis.
  </details>
 
  <!-- 👤 Members -->
  <h2 id="members">👤 Current Members</h2>
 
  <div class="card-grid">
    <div class="card">
      <img src="https://via.placeholder.com/100" />
      <h4>Yang Wang 王蛘</h4>
    </div>
    <div class="card">
      <img src="https://via.placeholder.com/100" />
      <h4>Xie Guangneng 谢广能</h4>
      <p>Student 研究生</p>
     </div>
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        <div style="text-align: center; width: 160px;">
       <img src="https://via.placeholder.com/100" />
       <img src="http://yangwalab.com/images/e/e1/Hu_yang_20250429.png?20250430025003" alt="胡杨" style="width: 120px; height: auto; border-radius: 0;">
       <h4>Xu Anran 徐安然</h4>
       <div style="font-weight: bold; margin-top: 10px;color: #000;">胡杨</div>
       <p>PhD Student 研究生</p>
       <div style="font-size: 14px; color: #666">2025年入学博士生</div>
     </div>
     </div>
     <div class="card">
     <div style="text-align: center; width: 160px;">
       <img src="https://via.placeholder.com/100" />
       <img src="http://yangwalab.com/images/2/22/Xieguangneng_head_photo.jpg?20250420033719" alt="谢广能" style="width: 120px; height: auto; border-radius: 0;">
       <h4>Zhang Wei</h4>
       <div style="font-weight: bold; margin-top: 10px;color: #000;">谢广能</div>
       <p>Master Student</p>
       <div style="font-size: 14px; color: #666">2025年入学硕士生</div>
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       <img src="https://via.placeholder.com/100" />
       <img src="http://yangwalab.com/images/b/b3/Xuanran_headphoto.jpg?20250420034001" alt="徐安然" style="width: 120px; height: auto; border-radius: 0;">
       <h4>Li Jie</h4>
       <div style="font-weight: bold; margin-top: 10px;color: #000;">徐安然</div>
       <p>Intern</p>
       <div style="font-size: 14px; color: #666">2025年入学硕士生</div>
     </div>
     </div>
   </div>
   </div>


   <!-- 📚 Publications -->
   <!-- 📙 发表文章 -->
   <h2 id="publications">📚 Selective Publications 代表性论文</h2>
   <h2 style="text-align: center; font-size: 26px; margin-top: 80px;">Publications 已发表研究论文</h2>
  <div style="font-size: 15px; color: #333; line-height: 1.8; text-align: left; padding-left: 20px;">
    <ol>
      <li><span style="text-decoration: underline;">Wang Yang</span>, Igor Baars, Ieva Berzina, Iris Rocamonde-Lago, Boxuan Shen, Yunshi Yang, Marco Lolaico, Janine Waldvogel, Ioanna Smyrlaki, Keying Zhu, Robert A Harris, Björn Högberg*. <strong>A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns</strong>. <em style="color: #007BFF;">Nature Nanotechnology</em>. 19, pages 1366–1374 (2024)</li>
      <li>Ioanna Smyrlaki, Ferenc Fördős, Iris Rocamonde-Lago, <span style="text-decoration: underline;">Wang Yang</span>, Boxuan Shen, Antonio Lentini, Vincent C Luca, Björn Reinius, Ana I Teixeira, Björn Högberg*. <strong>Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force</strong>. <em style="color: #007BFF;">Nature Communications</em>. 15, Article number: 465 (2024).</li>
      <li>Marco Lolaico, Sebbe Blokhuizen, Boxuan Shen, <span style="text-decoration: underline;">Wang Yang</span>, Björn Högberg*. <strong>Computer-Aided Design of A-Trail Routed Wireframe DNA Nanostructures with Square Lattice Edges</strong>. <em style="color: #007BFF;">ACS Nano</em>. 17, 7, 6565–6574 (2023).</li>
      <li>Miao Deng, Rong Guo, <span style="text-decoration: underline;">Wang Yang</span>, Jia-Xin Li, Jiao He, Man Li*, and Qin He*. <strong>Curbing Exosome Communications via Introducing Artificial Membrane Receptors for Metastatic Pancreatic Cancer Therapy</strong>. <em style="color: #007BFF;">Advanced Materials</em>. 35, 2303736 (2023).</li>
      <li>Jiaye Liu#, <span style="text-decoration: underline;">Wang Yang</span>#(co-first), Chunyang Mu#, Meng Li, Kewei Li, Shan Li, Wenshuang Wu, Lingyao Du, Xiaoyun Zhang, Chuan Li, Wei Peng, Junyi Shen, Yang Liu, Dujiang Yang, Kaixiang Zhang, Qingyang Ning, Xiaoying Fu, Yu Zeng, Yinyun Ni, Zongguang Zhou, Yi Liu, Yiguo Hu, Xiaofeng Zheng*, Tianfu Wen*, Zhihui Li*, Yong Liu*. <strong>Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement</strong>. <em style="color: #007BFF;">Nature Communications</em>. 13, Article number: 4308 (2022).</li>
      <li>Keying Zhu, <span style="text-decoration: underline;">Wang Yang</span>, Heela Sarlus, Keyi Geng, Erik Nutma, Jingxian Sun, Shin‐Yu Kung, Cindy Bay, Jinming Han, Jin‐Hong Min, Irene Benito‐Cuesta, Harald Lund, Sandra Amor, Jun Wang, Xing‐Mei Zhang, Claudia Kutter, André Ortlieb Guerreiro‐Cacais, Björn Högberg, Robert A Harris*. <strong>Myeloid cell‐specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation</strong>. <em style="color: #007BFF;">EMBO Reports</em>. 23: e54499 (2022).</li>
      <li><span style="text-decoration: underline;">Wang Yang</span>, Erik Benson, Ferenc Fördős, Marco Lolaico, Igor Baars, Trixy Fang, Ana I Teixeira, Björn Högberg*. <strong>DNA Origami Penetration in Cell Spheroid Tissue Models is Enhanced by Wireframe Design</strong>. <em style="color: #007BFF;">Advanced Materials</em>. 33, 2008457 (2021).</li>
      <li><span style="text-decoration: underline;">Wang Yang</span>, Igor Baars, Ferenc Fördős, Björn Högberg*. <strong>Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides</strong>. <em style="color: #007BFF;">ACS Nano</em>. 15, 6, 9614–9626 (2021).</li>
      <li>Toon Verheyen, Trixy Fang, Dominik Lindenhofer, <span style="text-decoration: underline;">Wang Yang</span>, Karen Akopyan, Arne Lindqvist, Björn Högberg, Ana I Teixeira*. <strong>Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers</strong>. <em style="color: #007BFF;">Nucleic Acid Research</em>. 48, 5777–5787 (2020).</li>
    </ol>
  </div>


  <ul>
  <!-- 会议论文 -->
    <li><b>Wang Y</b>, et al. Programmable DNA robot for cancer therapy. <i>Nature Nanotechnology</i>, 2024.</li>
  <h2 style="text-align: center; font-size: 24px; margin-top: 80px;">Conference paper 会议论文</h2>
   </ul>
  <div style="text-align: center; font-size: 15px; margin-top: 10px; color: #444;">
    3) 2025年6月,中国化学会第十二届DNA纳米技术研讨会,英文学术报告 (中国,成都),报告题目《Triplex DNA-MediatedLigandExposure for Tumor-Selective Cell Killing》; 2) 2024年4月,第21届纳米科学基础年度会议（FNANO2024),英文学术报告 (美国,snowbird),报告题目《A DNA-Based Robotic Device Exhibiting Controlled and Autonomous Presentation of Nano-patterned Cytotoxic Ligands in vivo》; 1) 2023年4月,第21届纳米科学基础年度会议（FNANO2024),英文学术报告 (美国,snowbird),报告题目《2024年4月,第21届纳米科学基础年度会议（FNANO2024),英文学术报告 (美国,snowbird),报告题目《Wireframe DNA origami engineering for immunotherapy》.
   </div>


   <!-- 📞 Contact -->
   <!-- 📞 联系 -->
   <h2 id="contact">📞 Contact</h2>
  <h2 style="text-align: center; font-size: 24px; margin-top: 80px;">Contact 联系方式</h2>
  <div style="text-align: center; font-size: 15px; margin-top: 10px; color: #444;">
    Address: 四川省成都市人民南路三段17号四川大学华西药学院，邮编：610041
    Email: yang_wang@scu.edu.cn; wangyangkiscu@gmail.com
  </div>
 
  <!-- 🤝 合作 -->
   <h2 style="text-align: center; font-size: 24px; margin-top: 80px;">Collaborators 合作伙伴</h2>
  <div style="text-align: center; font-size: 15px; color: #444; margin-top: 10px; letter-spacing: 0.3px;">
    四川大学华西药学院 • 哈佛医学院 Harvard Medical School & 丹娜法博癌症研究所 Dana-Farber Cancer Institute (Ming-Ru Wu Lab) • 卡罗林斯卡医学院 Karolinska Institute (Björn Högberg Lab)
  </div>


   <p>📍 West China School of Pharmacy, Sichuan University</p>
   <!-- 📸 合照 -->
   <p>📧 13547820971@163.com</p>
   <h2 style="text-align: center; font-size: 24px; margin-top: 80px;">Team Photo 组内活动</h2>
   <p>🌐 <a href="http://yangwalab.com" target="_blank">yangwalab.com</a></p>
   <figure style="text-align: center; margin-top: 20px;">
  <img src="http://yangwalab.com/images/thumb/9/97/WechatIMG487.jpg/1600px-WechatIMG487.jpg?20250419195926"
      alt="Group Photo"
      style="max-width: 100%; width: 800px; border-radius: 12px;">
  <figcaption style="margin-top: 8px; font-size: 16px; color: #555;">合成生物药物实验室 - 波士顿跨年烟花（2024年）</figcaption>
</figure>


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Latest revision as of 23:26, 15 June 2025


Group Introduction

SynBio Pharmaceutical Lab 合成生物药物实验室

We engineer programmable therapeutic systems at the intersection of synthetic biology and nucleic acid nanotechnology.

合成生物药物实验室专注三方面研究: 1)核酸折纸结构的设计与功能化，及其在药剂学中的纳米药物应用; 2)基于人工智能的合成生物学策略在免疫治疗中的应用探索; 3)合成细胞的构建与调控，及其在生物药剂学中的创新转化应用

Lab Members 课题组成员

王蛘
王蛘
四川大学华西药学院特聘研究员，博士生导师; 国家自然科学基金优秀青年科学基金项目（海外）
胡杨
胡杨
2025年入学博士生
谢广能
谢广能
2025年入学硕士生
徐安然
徐安然
2025年入学硕士生

Publications 已发表研究论文

  1. Wang Yang, Igor Baars, Ieva Berzina, Iris Rocamonde-Lago, Boxuan Shen, Yunshi Yang, Marco Lolaico, Janine Waldvogel, Ioanna Smyrlaki, Keying Zhu, Robert A Harris, Björn Högberg*. A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns. Nature Nanotechnology. 19, pages 1366–1374 (2024)
  2. Ioanna Smyrlaki, Ferenc Fördős, Iris Rocamonde-Lago, Wang Yang, Boxuan Shen, Antonio Lentini, Vincent C Luca, Björn Reinius, Ana I Teixeira, Björn Högberg*. Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force. Nature Communications. 15, Article number: 465 (2024).
  3. Marco Lolaico, Sebbe Blokhuizen, Boxuan Shen, Wang Yang, Björn Högberg*. Computer-Aided Design of A-Trail Routed Wireframe DNA Nanostructures with Square Lattice Edges. ACS Nano. 17, 7, 6565–6574 (2023).
  4. Miao Deng, Rong Guo, Wang Yang, Jia-Xin Li, Jiao He, Man Li*, and Qin He*. Curbing Exosome Communications via Introducing Artificial Membrane Receptors for Metastatic Pancreatic Cancer Therapy. Advanced Materials. 35, 2303736 (2023).
  5. Jiaye Liu#, Wang Yang#(co-first), Chunyang Mu#, Meng Li, Kewei Li, Shan Li, Wenshuang Wu, Lingyao Du, Xiaoyun Zhang, Chuan Li, Wei Peng, Junyi Shen, Yang Liu, Dujiang Yang, Kaixiang Zhang, Qingyang Ning, Xiaoying Fu, Yu Zeng, Yinyun Ni, Zongguang Zhou, Yi Liu, Yiguo Hu, Xiaofeng Zheng*, Tianfu Wen*, Zhihui Li*, Yong Liu*. Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement. Nature Communications. 13, Article number: 4308 (2022).
  6. Keying Zhu, Wang Yang, Heela Sarlus, Keyi Geng, Erik Nutma, Jingxian Sun, Shin‐Yu Kung, Cindy Bay, Jinming Han, Jin‐Hong Min, Irene Benito‐Cuesta, Harald Lund, Sandra Amor, Jun Wang, Xing‐Mei Zhang, Claudia Kutter, André Ortlieb Guerreiro‐Cacais, Björn Högberg, Robert A Harris*. Myeloid cell‐specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation. EMBO Reports. 23: e54499 (2022).
  7. Wang Yang, Erik Benson, Ferenc Fördős, Marco Lolaico, Igor Baars, Trixy Fang, Ana I Teixeira, Björn Högberg*. DNA Origami Penetration in Cell Spheroid Tissue Models is Enhanced by Wireframe Design. Advanced Materials. 33, 2008457 (2021).
  8. Wang Yang, Igor Baars, Ferenc Fördős, Björn Högberg*. Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides. ACS Nano. 15, 6, 9614–9626 (2021).
  9. Toon Verheyen, Trixy Fang, Dominik Lindenhofer, Wang Yang, Karen Akopyan, Arne Lindqvist, Björn Högberg, Ana I Teixeira*. Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers. Nucleic Acid Research. 48, 5777–5787 (2020).

Conference paper 会议论文

3) 2025年6月,中国化学会第十二届DNA纳米技术研讨会,英文学术报告 (中国,成都),报告题目《Triplex DNA-MediatedLigandExposure for Tumor-Selective Cell Killing》; 2) 2024年4月,第21届纳米科学基础年度会议（FNANO2024),英文学术报告 (美国,snowbird),报告题目《A DNA-Based Robotic Device Exhibiting Controlled and Autonomous Presentation of Nano-patterned Cytotoxic Ligands in vivo》; 1) 2023年4月,第21届纳米科学基础年度会议（FNANO2024),英文学术报告 (美国,snowbird),报告题目《2024年4月,第21届纳米科学基础年度会议（FNANO2024),英文学术报告 (美国,snowbird),报告题目《Wireframe DNA origami engineering for immunotherapy》.

Contact 联系方式

Address: 四川省成都市人民南路三段17号四川大学华西药学院，邮编：610041 Email: yang_wang@scu.edu.cn; wangyangkiscu@gmail.com

Collaborators 合作伙伴

四川大学华西药学院 • 哈佛医学院 Harvard Medical School & 丹娜法博癌症研究所 Dana-Farber Cancer Institute (Ming-Ru Wu Lab) • 卡罗林斯卡医学院 Karolinska Institute (Björn Högberg Lab)

Team Photo 组内活动

Group Photo
合成生物药物实验室 - 波士顿跨年烟花（2024年）

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